CMR-Analysis (including machine learning)
Shiqin Yu, MD
Dr.
Fuwai hospital
Beijing, Beijing, China (People's Republic)
Shiqin Yu, MD
Dr.
Fuwai hospital
Beijing, Beijing, China (People's Republic)
Xiuyu Chen, MD, PhD
Dr.
Fuwai hospital, China (People's Republic)
Zhixiang Dong
Dr.
Fuwai hospital, China (People's Republic)
Huaibing Chen
Dr.
Fuwai hospital, China (People's Republic)
Kai Yang, MD
Dr.
Fuwai hospital
Beijing, Beijing, China (People's Republic)
Gang Yin, BSc
Dr.
Fuwai hospital, Beijing, China (People's Republic)
Shihua Zhao, MD, PhD
Chief Physician
Fuwai Hospital
Beijing, Beijing, China (People's Republic)
Myocardial fibrosis is implicated as a potential substrate responsible for arrhythmias. We aimed to investigate myocardial fibrosis assessed by T1 mapping in patients with apparently idiopathic premature ventricular complexes (PVC), and to determine the relationship between this tissue biomarker and PVC features.
Methods:
Patients with frequent PVC ( >1000/24h) who underwent cardiac MRI between 2020 and 2021 were retrospectively evaluated. Patients were included if they had no indicator of known heart diseases on MRI. Healthy subjects were sex- and age-matched without contrast administration. High PVC burden was defined as the percentage of PVC >20%/24h.
Results:
A total of 70 patients and 70 healthy controls were included. Global T1 value was significantly higher in patients than in controls (P < 0.001). Extracellular volume was 26.03% ± 2.16% in the patients. Moreover, global T1 value showed a stepwise increasement in PVC tertiles (P = 0.03) but not for extracellular volume (P = 0.85). Patients with a non-left bundle branch block (LBBB) inferior axis morphology showed a higher global native T1 values than LBBB inferior axis pattern (P = 0.005). In addition, global T1 values correlated significantly with PVC burden (r = 0.28, P = 0.02). In the multivariate analysis, global T1 value independently correlated with high PVC burden (odds ratio: 1.22 per 10 ms increase, P = 0.02).
Conclusion: Prolonged global T1, a marker of interstitial fibrosis, was detected in patients with apparently idiopathic PVC and was significantly associated with non-LBBB inferior axis morphology and high PVC burden.