(DCP077) MEAL ENRICHED IN FRUCTOSE INCREASES INFLAMMATION WITHOUT INFLUENCING EXERCISE INFLAMMATORY RESPONSE IN MEN WITH TYPE 2 DIABETES

Background: Type 2 diabetes (T2DM) is associated with chronic inflammation which increases insulin resistance and cardiovascular risk. Fructose consumption as well as exercise increase inflammation in the short term in the general population. The combined effect of fructose consumption and exercise on inflammation in T2DM is unknown. The objective of this study to assess the impact of fructose ingestion on the exercise related acute inflammatory response in adults with T2DM.

METHODS AND RESULTS: Ten men (age: 55±12 years, BMI: 29.8±5.1 kg/m2) with T2DM (HbA1C: 0.059±0.006) without insulin treatment or cardiac conditions completed five 60-min moderate-intensity (60% VO2max) exercise sessions in a single-blind crossover design under the following conditions: 1) fasted state and, 2h after an equal calorie counts meal enriched in; 2) glucose, 3) fructose, 4) fat, and 5) aspartame. Blood samples were taken 15 minutes prior to exercise (i.e. 2 hours after the standardized meal), and every 15 minutes until 30 minutes into post-exercise recovery (time 90) for C-reactive protein (CRP). Other markers, interleukin 6 (IL-6), macrophage inflammatory protein-1 alpha (MIP-1α), and monocyte chemoattractant protein 1 (MCP-1) were measured at the start of exercise (time 0) and after the exercise session (at 60 and 90 min). CRP levels were higher during the exercise session following ingestion of fructose compared with glucose (2.93 vs 1.66 mg/L, p=0.005). No significant differences were observed between time points. MCP-1 levels increase after the ingestion of fructose compared to the fasted state (161.1 vs 117.0 pg/L, p=0.003). No interaction was found between exercise and meal content.

Conclusion: Our results suggest that fructose leads to an increased inflammatory response when compared to other macronutrients, which could be deleterious in men with T2DM. The lack of interaction between time and meal condition suggests that the pre-exercise meal does not modulate the acute exercise inflammatory response. Further studies are needed to evaluate whether exercise intensity or exercise type leads to different results, as well as the possibility of a sex-specific response.