Mina S. Makary, MD (he/him/his)
The Ohio State University Wexner Medical Center
To review the current applications, recent evidence, and future directions for histotripsy in interventional oncology.
Histotripsy is an emerging non-invasive, non-thermal ablation technique which uses ultrasound waves to generate mechanical forces that cause cell lysis. This technique is currently under investigation for use in a variety of clinical settings including the treatment of cardiovascular, neurologic, genitourinary, and oncologic disease. Recent data supports histotripsy as an excellent modality for liver tumors in particular, demonstrating excellent technical success and the presence of an abscopal effect. As a result, it is essential that interventional radiologists become familiar with the unique mechanism, applications, current data and future directions for histotripsy.
Clinical Findings/Procedure Details:
This educational exhibit will: (1) describe the mechanism of histotripsy, (2) review the current applications under investigation, (3) describe the abscopal effect in the treatment of tumors, (4) present the clinical management of liver tumors using histotripsy, (5) review the procedural indications, contraindications, and potential risks, and (6) review the current literature, treatment outcomes, and future therapies.
Conclusion and/or Teaching Points:
After reviewing this exhibit, the viewer will understand the mechanism of histotripsy, the variety of clinical applications currently under investigation for this technique, treatment outcomes, and current literature and future directions for histotripsy.