James Z. Hui, MD, PhD
Interventional Radiology, Stanford University
Disclosure(s): No financial relationships to disclose
Daniel Y. Sze, MD, PhD (he/him/his)
Professor, Editor in Chief
Stanford University; Journal of Vascular and Interventional Radiology
In all patients, CTCs were enriched in the hepatic vein samples compared to the peripheral vein samples, ranging from 1.9-fold to >1000-fold (Table). In the patient with lowest CTC enrichment, there was a general paucity of EPCAM+/CK+/CD45- CTCs despite extensive disease burden, but instead an abundance of EPCAM-/CK+/CD45- cells, which may suggest the presence of CTCs with atypical surface makers in subsets of patients, as has been previously reported.*
Conclusion: Selective hepatic vein sampling using routine IR techniques can increase the yield of CTCs for clinical and basic science research into GI malignancies. This may allow IRs to contribute to the development of better prognostic biomarkers, detect micro-metastases, and advance research on the biology of metastasis.