Multiparametric Mapping

1357002 - Multiparametric SASHA combined T1 and T2 mapping: sex related differences and reference ranges at 1.5T

Wednesday, January 25, 2023

Location: E-POSTER

Presenting Author(s)

AA

Aderonke T. Abiodun, MBChB

Clinical Research Fellow
University College London, United Kingdom

Primary Author(s)

JA

Jessica Artico, MD

Clinical Research Fellow
St Bartholomew's Hospital, England, United Kingdom

Co-Author(s)

HK

Hibba Kurdi, MD, BSc

Cardiology Fellow
Barts Health NHS Trust, London, UK
London, United Kingdom
GJ

George Joy, MBBS

Research Fellow
University College London, United Kingdom
RA

Robert Adam

Clinical Research Fellow
Barts Heart Centre at St Bartholomew's Hospital, Romania
IP

Iain Pierce, PhD

Scientist
Barts Heart Centre at St Bartholomew's Hospital, United Kingdom
HS

Hunain Shiwani, MD

Clinical Research Fellow
University College London and Barts Heart Centre, United Kingdom
Rhodri Davies, MD, PhD

Associate clinical professor
University College London
London, Wales, United Kingdom
HX

Hui Xue, PhD

Director, Imaging AI Program
National Institutes of Health
Bethesda, Maryland, United States
KC

Kelvin Chow, PhD

Staff Scientist
Siemens Healthineers
Chicago, Illinois, United States
James C. Moon, MD

Clinical Director, Imaging
Barts Heart Centre and UCL
London, England, United Kingdom
PK

Peter Kellman, PhD

Senior Scientist
National Institutes of Health, Maryland, United States

Background: Multiparametric SAturation-recovery single-SHot Acquisition (mSASHA) allows combined acquisition of T1 and T2 maps provides accurate cardiac T1 and T2 quantification in a single acquisition with similar precision to MOLLI and T2 -prepared balanced SSFP^1-3. However, reference ranges and data on age and sex-related differences are currently lacking. Aim of the present study is to provide reference ranges for mSASHA, comparing them to MOLLI and to T2 -prepared balanced SSFP.

Methods: 70 adult healthy volunteers (31 men, 39 women) were consecutively recruited and scanned in 2 London Hospitals. Exclusion criteria were history or symptoms of cardiovascular disease, being severely underweight or severe obesity (BMI < 14 or >36). The imaging included cines, native mSASHA, T1 mapping (MOLLI) and T2 mapping.

Results: The average age was 39±11 years and was similar in both sexes. Mean native T1 and T2 values were: 1018±64ms for T1 MOLLI, 1209±60ms for T1 mSASHA, 48±4ms for T2, 43±3ms for T2 mSASHA (table 1). Females had higher T1 and T2 values, irrespective of the mapping technique. In particular, for females, T1 mapping was +12ms for both MOLLI and mSASHA and T2 mapping was +1ms for both Myomaps and mSASHA.

Conclusion: We hereby provide reference ranges for T1 and T2 mSASHA at 1.5T. T1 and T2 values are higher in females in all sequences, confirming that the findings of previous studies^2-4are also reproduced with T1 and T2 mSASHA sequences.