1345765 - Cine MRI-derived radiomics features of the blood pool: Periodicity, Specificity, and Reproducibility

Radiomics has been applied to evaluate cardiovascular diseases (CVDs). However, radiomics features of the heart are mainly acquired on the wall of left ventricle. The aim of the present study was to test the hypothesis that cine MRI-derived radiomics features of the blood pool can represent cardiac function and motion.

Methods:

Cine MRI images of 26 healthy volunteers (17 male, mean age: 51.2 ± 15.6 years, range: 27 – 75 years old) were retrospectively enrolled. Thirteen participants had repeated MRI within 14 days. The radiomics features (107 features in 7 classes) of the blood pool of the left/right ventricle/atrium (LV/RV/LA/RA) were extracted on 4-chamber cine images (25 phases). Figure 1. Peak values of features related to end-diastolic (or maximal) volume, end-systolic (or minimal) volume, ejection fraction (EF), and longitudinal strain of the corresponding chambers. The intraobserver, interobserver and scan-rescan agreement for radiomics features were also tested.

Results:

Time curves showed that most radiomics features in the blood pool regularly vary throughout a cardiac cycle. There were significant differences on the levels of 69 (64%) features acquired from LV, RV, LA and RA (ANOVA, p < 0.05). Figure 2.

Peak values of chamber-specific blood pool radiomics features were widely correlated with traditional cardiac function and motion indices of corresponding chambers.

For the LV blood pool, 21 features were related to the EDV (r: 0.429 – 0.761), 21 features were associated with the ESV (r: 0.421 – 0.804), 1 feature was related to the EF (r = 0.409), and 6 features were associated with the longitudinal strain (r: 0.401 – 0.542). Additionally, 44 of 107 (41%) radiomics features acquired from the LV blood pool were significantly related to their counterparts acquired from the LV myocardium (r: 0.423 – 0.975).

For the RV blood pool, 23 features were related to the EDV (r: 0.414 – 0.717), 26 features were associated with the ESV (r: 0.407 – 0.811), 14 features were related to the EF (r: 0.406 - 0.604), and 16 features were associated with the longitudinal strain (r: 0.412 – 0.615).

For the LA blood pool, 36 features were related to the maximal volume (r: 0.417 – 0.814), 20 features were associated with the minimal volume (r: 0.406 – 0.644), 3 features were related to the EF (r: 0.421 - 0.453), and 4 features were associated with the longitudinal strain (r: 0.402 – 0.489). Figure 3.

For the RA blood pool, 24 features were related to the maximal volume (r: 0.409 – 0.87), 52 features were associated with the minimal volume (r: 0.4 – 0.831), 3 features were related to the EF (r: 0.407 - 0.472), and 16 features were associated with the longitudinal strain (r: 0.404 – 0.545).

Conclusion: Cine-MRI-derived radiomics features within LV/RV/LA/RA are associated with traditional cardiac function and motion indices of corresponding chambers. Radiomics features of the blood pool have the potential to become novel quantitative imaging biomarkers in cardiovascular medicine.