UCLA
Lin Lin, MD, Ph.D., is a resident physician at UCLA Urology. She was born and raised in Wenzhou, China. She studied Biosciences and Biotechnology at Tsinghua University in Beijing, China. After graduation, she moved to Los Angeles, California, and completed her Ph.D. training with Dr. Jonathan Braun at UCLA, studying human immunity and inflammatory bowel disease. After completing her Ph.D., she attended Cleveland Clinic Lerner College of Medicine, Case Western Reserve University for medical school with a full scholarship. During medical school, she spent a dedicated year of research investigating prostate cancer radiation immunotherapy with Dr. Robert Reiter at UCLA.
Dr. Lin Lin is spending her residency research year investigating the metabolism and pathogenesis of renal oncocytoma, under the guidance of Dr. Brian Shuch, UCLA Urology associate professor, director of the Institute of Urologic Oncology Kidney Cancer Program, and Henry Alvin and Carrie L. Meinhardt Chair for Kidney Cancer Research; and Dr. David Shackelford, associate professor in the Division of Pulmonary and Critical Care Medicine and an expert in signal transduction and cancer metabolism. Renal oncocytoma is one of the most commonly resected benign renal masses, but it is difficult to differentiate these lesions from malignant renal cell cancers based on preoperative imaging. It is known oncocytomas are densely packed with dysfunctional mitochondria, which could be secondary to increased biogenesis or decreased breakdown. However, we have limited knowledge how the mitochondrial turnover process is impaired in oncocytoma. Using next-generation sequencing, gene expression profiling, metabolic functional assays, Western blot, and immunohistochemistry, Dr. Lin aims to uncover the mechanism of defective autophagy in oncocytoma and to devise a new imaging modality to help preop identification of oncocytic tumors and reduce unnecessary surgical resections.
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Friday, April 28, 2023
7:00 AM – 9:00 AM CST
Saturday, April 29, 2023
9:40 AM – 9:50 AM CST