Session: MP60: Bladder and Urethra: Anatomy, Physiology and Pharmacology
MP60-19: Systematic Oxidative Stress Indexes Predicts the Prognosis in Patients with Urothelial Carcinoma of the Upper Urinary Tract After Radical Nephroureterectomy
Introduction: Upper urinary tract urothelial carcinoma (UTUC) which is an aggressive malignant tumor usually has a very poor prognosis with 5-year specific survival reaching <10% for pT4 UTUC. Oxidative stress plays an important factor in the occurrence and development of malignancy. However, the relationship between oxidative stress and UTUC prognosis remains elusive. The study aims to evaluate the prognostic value of systematic oxidative stress indexes as a predictor of patient outcomes in UTUC after radical nephroureterectomy. Methods: The clinical data of 483 patients with UTUC who underwent radical nephroureterectomy were analyzed. Patients were categorized according to an optimal value of systematic oxidative stress indexes (SOSI), including fibrinogen (Fib), gamma-glutamyl transpeptidase (?-GGT), creatinine (CRE), lactate dehydrogenase (LDH) albumin (ALB). Kaplan–Meier analyses were used to investigate associations of SOSI with overall survival (OS) and progression-free survival (PFS). Moreover, the associations between SOSI and OS were assessed with univariate and Multivariate analyses. Results: The Kaplan–Meier survival analysis showed a significant discriminatory ability for death and progression risks in the two groups based on the SOSI.Multivariate Cox proportional hazards models manifested that SOSI was an independent prognostic indicator for OS ( p = 0.006). SOSI and clinical variables were selected to establish the nomogram.The calibration curves of the nomogram showed high consistencies between the predicted and observed survival probability. Decision curve analysis curves showed that the nomogram could better predict the 1-year, 3-year, and 5-year OS. Conclusions: The SOSI is an independent unfavorable predictor of OS in patients diagnosed with UTUC undergoing RNU.Therefore, incorporating SOSI into currently available clinical parameters may improve clinical decision-making. SOURCE OF Funding: No
