Introduction: Independently performed procedures by well-trained advanced practice providers (APP) facilitate access to specialized care. We sought to compare outcomes between physicians and APPs with intralesional Collagenase Clostridium histolyticum (CCH). Methods: Men receiving CCH between 2014-2021 at our institution by four physicians and four APPs were included in an IRB-approved database. CCH was delivered as a series of 8 injections per protocol. Patient demographics, procedural-related adverse events, and curvature changes were recorded. We describe an “APP-ratio”, defined as percentage of total injections administered by an APP per patient. Results: After excluding patients who did not complete the entire CCH course and those who did not return for final assessment, 150/406 patients were analyzed. Mean baseline penile curvature was 66.2º (SD 23). Mean absolute and percent improvements in curvature were 21.7º (SD 18) and 33% (SD 27). The mean APP ratio was 69%, and 133 patients (89%) had at least 25% of their injections performed by an APP. There was no significant difference in absolute or relative curvature improvement based on the APP-ratio [Figure 1]. The frequency of adverse events (pain, swelling, and hematoma). Conclusions: In our high-volume CCH practice, APPs achieve the same outcomes and safety compared to physicians. Greater training efforts expand access to care for patients with PD. SOURCE OF Funding: N/A
