Introduction: Surgical therapy for Peyronie's disease (PD) is reserved for patients with severe penile deformity that fails to improve with medical treatment and impedes sexual intercourse. Surgical treatment should be delayed until the acute inflammatory phase has resolved and should be considered in patients with deformity that impairs sexual function. Plaque incision or excision with grafting has been suggested as an option in patients with a penile curvature greater than 60°, a shortened penis, and/or an hourglass or complex deformity. Our purpose is to assess efficacy, complications and degree of patient satisfaction of preputial skin graft for treatment of penile curvatures by grafting corporoplasty. 68 patients (15-76 y) were treated between 2012 and 2021, with a degree of curvature between 30° and 80°at Fidenza Hospital. The patients analyzed had more than 17 valutaden with IEFF-5 score before the surgical procedure. Methods: The surgery was performed by subcoronal incision, next degloving and preputial patch preparation. Next detachment of the nervous vascular bundle and incision of the double inverted T plate and application of the preputial patch. Compressive medication and catheterization. All patients were hospitalized for 4 days with removal of compressive medication on the third day and removal of the bladder catheter. Post-operative medication about 7 days after discharge with no evidence of major complications (about 10 patients had penile hematoma resolved with conservative therapy). About 6 months after surgery, patients were asked about the degree of satisfaction valueted IEFF-5 and the possible appearance of postoperative penile curvatures. Results: Of the 68 patients operated 44 (64.7% of patients) had an IEFF-5 greater than 17 without a recurrence of curvature, 19 patients had an IEFF-5 less than 17 (27.9%) without a recurrence of curvature, 5 patients (7.4%) had an IEFF-5 greater than 17 but had a penile curvature recurrence of less than 30%. Only 10 patients post-operative complication. Conclusions: The aim of the surgical treatment in Peyronie's disease is to correct the deformity while preserving or improving erectile capacity of the penis. Appropriate treatment options should be individualized according to the patients' expectations and erectile capacity. Preputial graft has similar outcome compared to other Autologous grafts like Vein, Tunica vaginalis, Tunica albuginea, Buccal mucosa, Lingual mucosa, Fascia lata. SOURCE OF Funding: None
