Director AstraZeneca -, Massachusetts, United States
SIG Description The mission of the Absorption, Distribution, Metabolism and Toxicology SIG is to advance drug discovery and development by promoting the discussion and dissemination of principles, topics and ideas for the integration of higher throughput technologies with methods for determining pharmacokinetics, metabolism and toxicity. The goal is to accelerate the drug discovery pipeline and shorten the time of the development of new drugs and improve quality of life. This special interest group creates a bridge and network between scientists working in the fields of medicinal chemistry, pharmacokinetics, pharmacology, and preclinical research.
Session Information Title: Leveraging in vitro drug-drug interaction data for early clinical risk assessment
Drug-drug interactions stemming from inhibition or induction of drug metabolizing enzymes can have important consequences including modulation of drug exposure. This presentation will highlight recent data demonstrating the utility of hepatocytes and simple mechanistic models to predict clinically relevant inhibition or induction interactions.