Assay Development and Screening
This session will focus on the utility of DNA-encoded libraries for hit identification. Specific attention will be paid to strategies for selection including screening for functional activity, eliminating non-specific binders, and managing challenging targets such as DNA-binding proteins and membrane proteins. We will also look at employing ML/AI for data analysis, triaging hits to make off-DNA, and discuss challenges in elucidating the real hit from the chemical recipe and engage in discussions on library scale and diversity.
Micah Steffek, MS – Genentech
Xiaoyu Li, PhD The University of Chicago; B.S. Peking University – The University of Hong Kong