Novartis, Massachusetts, United States
Markus Schirle received his master’s degree in biochemistry at University of Tuebingen, Germany and received his Ph.D. there in 2001 for his work with H.G. Rammensee on the identification of disease-associated MHC peptide by mass spectrometry-based approaches. After postdoctoral studies in proteomics with Alfred Nordheim, he joined Cellzome (now GSK, Heidelberg, Germany) from 2001 - 2007, where his work focused on protein and small molecule affinity proteomics for target identification (ID) and mechanism of action (MoA) studies. Joining Novartis in 2007, he established an independent platform for chemical and affinity proteomics for target ID and MoA studies in what is now the Chemical Biology and Therapeutics department. He is currently leading a group that is dedicated to identification and characterization of compound-protein interactions using proteomics, chemical biology, in vitro biophysics and biochemistry as well as structural biology and co-leads the Novartis-Berkeley Center for Proteomics and Chemistry Technologies (NB-CPACT). With his team he is responsible for affinity-based approaches to target ID/MoA as well as applications of covalent chemoproteomics and complementary approaches to the identification of ligandable pockets and chemical starting points for Novartis projects globally as well as the exploration of new modalities.
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Tuesday, February 8, 2022
5:00 PM – 5:30 PM