Laboratory Research
The antimicrobial agent PHMB (polyhexamethylene biguanide), is known for its use in various medical applications e.g. Contact Lens solutions, mouthwashes. More recently PHMB has demonstrated to be effective in wound care products at reducing microbial bioburden.
A silicone foam wound dressing containing PHMB has been developed for exudate management and effective antimicrobial efficacy. This study aims to collate known information to assess the uses and benefits of PHMB, in addition to demonstrating the performance capabilities of the Silicone PHMB foam dressing.
Methods:
A literature review will be performed to understand the mode of action of PHMB.
In vitro testing of the Silicone PHMB foam device to demonstrate its performance characteristics includes: Antimicrobial efficacy (log reduction), Absorbency, Peel Adhesion.
Results:
Two modes of action identified for PHMB which focus on the cell membrane disruption and alternative mechanism based on the selective binding and condensing of chromosomes.
The log reduction data demonstrates the device to achieve a >4 log reduction over a 7 day challenge period, with some microorganisms having a >4 log reduction obtained within 24hrs.
The hydrophilic foam in Silicone PHMB foam dressings provides excellent total fluid handling properties and the perforated silicone wound contact layer allows for gentle removal of the dressing making it suitable for use on fragile skin whilst providing secure adhesion over wear time.
Discussion:
A review on the mode of action has highlighted the benefits of PHMB in wound healing, and has indicated PHMB to be a credible alternative to traditional topical antimicrobials.
The Silicone PHMB foam dressing is capable of absorbing exudate from the wound and is efficacious in the management of bioburden. The fast action of PHMB allows for antimicrobial efficacy ancillary to healing by primary intention without contributing to antimicrobial resistance
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