.jpg "Ian Frew, PhD, BSc photo")
University Medical Center Freiburg, Germany
Our research group focuses on the study of clear cell renal cell carcinoma. We study the entire process of tumour formation, beginning with the molecular and cellular mechanisms that underlie the breakdown of normal epithelial proliferative homeostasis, the evolution of tumour cells and parallel evolution of the tumour microenvironment, as well as the process of metastasis. Our major experimental approach is to generate accurate autochthonous mouse tumour models using conventional mouse genetics, as well as novel genetic systems that we have developed. From the therapeutic perspective, we conduct pre-clinical studies to attempt to uncover specific vulnerabilities of cancer cells that are dictated by their underlying mutational genotype and their microenvironment.
Disclosure information not submitted.
Saturday, April 23, 2022
10:10 – 10:20 CEST