Introduction: The role of human papillomavirus (HPV) in prostate cancer is controversial. This prospective study intended to show the direct relationship between HPV infection and prostate cancer
Methods: 59 consecutive patients with suspicious prostate cancer underwent echo guided transrectal biopsy. Compared to standard, three additional fresh bioptic cores have been used for molecular biology investigation for HPV DNA research utilizing AMPLIQUALITY HPV-TYPE EXPRESS v.3.0 kit.
Results: Histological analysis confirmed the diagnosis of prostate adenocarcinoma in 37 men (62,7%), ASAP (Atypical small acinar proliferation) in 4 (6,8%), Chronic inflammation in 10 (16.9%), BPH (Benign prostatic hyperplasia) in 7 (11,9%), HGPIN (High-grade prostatic intraepithelial neoplasia) (1.7%) in 1 man. No HPV-DNA was found on a total of 177 prostate biopsy samples, regardless of the histological nature of the lesion.
Conclusions: There is no HPV tropism, whatever the genotype, for the prostate epithelium and there is no direct link between HPV and prostate adenocarcinoma.