Brigham and Women's Hospital
My ultimate research goal is to establish as an independent surgeon-scientist focused on understanding the molecular mechanisms of resistance to therapy of genitourinary tumors. My medical and surgical training allied with research experience in a wide variety of topics give me a solid background to explore molecular and immune mechanisms involved in bladder cancer aggressiveness.
During the second year of my urology residency in Portugal, I decided to move to the US to pursue a Ph.D. at Johns Hopkins School of Medicine. My interest in cancer biology dates back to my graduate work focused on alterations in the Notch and PTEN pathways involved in prostate cancer progression and metastasis. I decided to continue at Johns Hopkins as research fellow to explore genomic and epigenetic alterations that switch cellular programs of senescence into tumorigenesis. This work focused on perturbations of cell states that lead to cancer progression upraise my interest to understand mechanisms of resistance to therapy using high-throughput computational techniques in urologic cancers, particularly in bladder cancer.
These last seven years of residency and fellowship have been extremely fruitful to learn clinical and surgical management of urological cancers complementing my previous research work. As a future Urologic Oncologist focused on treating patients with bladder cancer, I am intrigued by the heterogenous tumor response to systemic therapy and inability to definitively recommend upfront surgery.
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Sunday, May 15, 2022
2:23 PM – 2:31 PM