Boston Children's Hospital and Harvard Medical School
Rosalyn Adam, PhD is Director of Urology Research at Boston Children's Hospital and Associate Professor of Surgery at Harvard Medical School. She is a cell biologist and biochemist by training. Dr. Adam's research focuses on understanding the molecular basis of hollow organ pathobiology, with a focus on tissue remodeling and alterations in smooth muscle physiology, but also with interests in tumor biology and cancer progression. The major areas of interest in her laboratory are: (1) the elucidation of neuropilin 2-dependent signaling in smooth muscle contractility and relaxation in the urinary tract, and the exploitation of this axis to modulate smooth muscle contractility in the setting of urinary tract obstruction; (2) delineation of the molecular landscape that underlies tissue remodeling in the bladder following spinal cord injury, investigation of mechanisms of action of the purine nucleoside inosine in mitigation of neurogenic detrusor overactivity, and optimization of strategies for its clinical use in patients; (3) investigation of mechanisms regulating receptor tyrosine kinase signaling in bladder cancer, and the role of the EGFR/c-MET regulator endophilin A1 in regulation of sensitivity to tyrosine kinase inhibitors.
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