(PO09-04-22) A Novel Approach to Maintain Physiological Ketosis During Intermittent Fasting With the Consumption of a Fast BarTM and Coffee or Tea: a Randomized, Controlled Study

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Presenting Author(s)

SD

Shauna Davis, MS
– Dietetic Intern/Research Associate, L-Nutra, Inc., Los Angeles, California, United States

Co-Author(s)

WH

William Hsu, MD
– L-Nutra, Inc.
AH

Angie W. Huang, MS, RDN
– L-Nutra, Inc.
MW

Min Wei, PhD
– L-Nutra, Inc.

Disclosure(s):

Shauna Davis, MS: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: Intermittent fasting has gained popularity in promoting health and been proposed to combat metabolic diseases. The study aimed to evaluate the effects of consuming a Fast Bar^TM (FB) with coffee or tea in extending physiological ketosis associated with time-restricted eating (Clinicaltrial.gov: NCT04790552).

Methods: We conducted the study remotely during the COVID-19 pandemic with healthy adults. Participants were randomized into 4 groups: water-only fast (overnight for 15 hours), FB as a nighttime snack, FB+coffee or FB+tea in the morning. Blood ketone (BHB) and glucose levels were measured hourly for 4 hours (Precision Xtra Blood Ketone & Glucose Monitoring System, Abbott) after consuming study foods. Subjects also completed a satiety and mood survey.

Results: 84 of the 89 enrolled participants completed the study. There was no postprandial glucose increase after consuming the Fast Bar with either black coffee or tea. The mean (SD) BHB AUC_0–4 for nighttime FB, FB+coffee, FB+tea, or water-only fast were 1.40 (0.81), 1.22 (0.73), 1.11 (0.45), 1.36 (0.78) mM∙h, respectively. Despite a delay in BHB increase 1 hour after consuming the Fast Bar, the 4-h ketone and glucose AUCs of the Fast Bar groups were similar to those of subjects water-fasted for 19 hours (one-way ANOVA with Dunn’s multiple comparison test).

Conclusions: Fast Bar^TM can be used as a nighttime snack, or with coffee or tea in the morning, to extend physiologic fasting state comparable to a 19-h water fasting. Fast Bar^TM may be used to support intermittent fasting or time-restricted eating pattern while providing satiety.

Funding Sources: Fully funded by L-Nutra, Inc.