Research Scientist W. G. (Bill) Hefner VA Healthcare System Salisbury, North Carolina, United States
The study examines magnetoencephalography (MEG)-derived functional brain connectomes in 181 combat-exposed veterans to determine if there are differential effects of mild traumatic brain injury (TBI) that occurrs in a deployment or non-deployment setting. This is a cross-sectional/observational study using validated structured clinical interviews to determine TBI history and PTSD diagnosis. Connectomes were constructed on an individual basis using active brain regions in the resting-state. Results demonstrate distinct effects of mild TBI on the functional brain connectome when sustained in a deployment versus non-deployment context. These results are consistent with a growing body of evidence demonstrating differences in outcomes of mild TBI acquired in a deployment context from those acquired in a non-deployment context.
Describe differences in chronic outcomes of mild TBI based on the context of the injury (deployment or non-deployment).
Discuss how the context of mild TBI acquisition produces distinct profiles of changes to the functional connectome.
Discuss the implications of chronic changes in brain function following mild TBI for service members and veterans and how these chronic changes inform current conceptualizations and treatment of mild TBI.