C0521 - The National Trends and Hospitalizations of Patients with Hereditary Hemochromatosis in the United States: Insights From the National Inpatient Sample

Monday, October 24, 2022

3:00 PM – 5:00 PM ET

Location: Crown Ballroom

Has Audio

Presenting Author(s)

Abdullah Sohail, MD

The University of Iowa Hospitals and Clinics
Iowa City, IA

Abdullah Sohail, MD¹, Khadija Naseem, MD², Ahmad Khan, MD³, Kyle E. Brown, MD⁴
¹The University of Iowa Hospitals and Clinics, Iowa City, IA; ²Cleveland Clinic Foundation, Cleveland, OH; ³Case Western Reserve University, Cleveland, OH; ⁴University of Iowa Hospitals and Clinics, Iowa City, IA

Introduction: Hereditary hemochromatosis (HH) is a disorder of increased intestinal iron absorption leading to total body iron overload. Although it is among the most common genetic diseases globally, no large-scale nationwide data is available regarding HH-related hospitalizations in the United States. Our study aimed to find on a national level the demographics of the patients with HH, inpatient mortality, and resource utilization using the national inpatient database (NIS).

Methods: We queried the nationwide inpatient (NIS) 2016-2019 databases using the ICD-10 CM codes to identify all the patients hospitalized with hereditary hemochromatosis (HH). We excluded patients under 18 years. The primary outcome of our study was to do an exploratory analysis and determine the baseline demographic characteristics of patients admitted with HH. The secondary outcomes included in-hospital mortality, length of stay (LOS), hospitalization cost, and outcomes.

Results: A total of 196 adult patients with HH were admitted in the United States with a mean age of 59.3 years. The majority of the patients were males (55%) and Caucasians (97.2%). The mean length of stay was 6 days, and a total of 10 patients (0.5%) died in the hospital. Medicare (47.2%) was the most common insurance, and most of the patients were admitted to large tertiary care hospitals. Patients with concomitant Alcoholic Liver Disease (ALD) had greater LOS (7.5 days vs. 6 days) than patients without ALD. The rest of the demographics are shared in the table.

Discussion: Our study demonstrated that most of the patients admitted with HH are Caucasians and males. The mean LOS is 6 days. The total mean cost of hospitalizations is $21,763.The HH patients with concomitant Hepatitis C and Alcoholic Liver Disease have higher healthcare utilization and worse outcomes than other patients. So, patients with HH should be screened for Hepatitis C and alcoholic Liver disease to improve the outcomes for these patients.

Patient Characteristics	Hereditary Hemochromatosis (HH)
No. of patients	196
Male (%)	109(55.7%)
Mean age, (SD) years	59.38
Race [N, %]
Caucasian	190(97.04%)
African American	0
Hispanic	0
Asian	6(2.96%)
Charlson Comorbidity Index Score [N, %]
O	56(28.71%)
1	47(24.07%)
2	19(9.56%)
3 or more	74(37.63%)
Median Income (Zip Codes) [N, %]
$1-$38,999	25(12.97%)
$39,000-$47,999	48(24.29%)
$48,000-$62,999	38(19.17%)
>$ 63,000	85(43.54%)

Insurance Provider [N, %]
Medicare	93(47.28%)
Medicaid	14(7.03%)
Private	84(42.94%)
Others	2.7%

Hospital Characteristics
Hospital teaching Status [N, %]
Non-Teaching	94(48.05%)
Teaching	102(51.94%)

Hospital Bed Size [N, %]
Small	35(17.79%)
Medium	63(32.07%)
Large	98.2(50.12%)

Hospital Location [N, %]
Rural	4(1.8%)
Urban	192(98.11%)

Outcomes	HH HH & Hep C HH & ALD
Mortality, no. %	10 (0.5%) 10(50%) 0
Length of Stay (SD)	6 5.9 7.5
Hospitalization cost (SD)	$21,763 $38,161 $43,962

Table: Table: Baseline patient and hospital characteristics and outcomes for HH-related hospitalizations

Disclosures:

Abdullah Sohail indicated no relevant financial relationships.

Khadija Naseem indicated no relevant financial relationships.

Ahmad Khan indicated no relevant financial relationships.

Kyle Brown indicated no relevant financial relationships.

Abdullah Sohail, MD¹, Khadija Naseem, MD², Ahmad Khan, MD³, Kyle E. Brown, MD⁴. C0521 - The National Trends and Hospitalizations of Patients with Hereditary Hemochromatosis in the United States: Insights From the National Inpatient Sample, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.