B0707 - A Rare Cause of Upper Gastrointestinal Bleeding: Gastric Synovial Sarcoma

Javier A. Ortega Balasquide, MD¹, Ubaldo Madera Sanchez, MD², Carlos G. Micames, MD³, Jorge Pelet, MD⁴, Roberto Vendrell, MD^2
1Universidad Central del Caribe Internal Medicine Residency, San Juan, Puerto Rico; ²Universidad Central del Caribe Internal Medicine Residency, Bayamon, Puerto Rico; ³Hospital Bella Vista, Mayaguez, Puerto Rico; ⁴Hospital Metropolitano, San Juan, Puerto Rico

Introduction: Synovial sarcoma is an uncommon type of malignant mesenchymal neoplasm commonly found within joints of the extremities and very rarely found in the GI tract. Genetic sequencing techniques used as an adjunct to histochemical markers have proven indispensable for diagnosis following biopsy. We present a rare subtype of soft tissue neoplasm called primary gastric synovial sarcoma as cause for gastrointestinal bleeding in a middle-aged Hispanic patient.

Case Description/Methods: A 51-year-old male with a medical history of Hypertension, and Diabetes was brought to the ER due to a syncopal episode. Patient denied abdominal pain, weight loss, hematemesis, hematochezia, hematuria, or melena. Physical exam was remarkable only for pale conjunctiva. Laboratory results remarkable for a hemoglobin of 5 g/dL warranting multiple packed red blood cell transfusions. Colonoscopy was performed with normal findings. Following upper GI endoscopy, a mid gastric body 3 cm polypoid irregular mass with shallow ulcerations was found. The patient was referred for endoscopic ultrasound revealing a 25 by 21 mm heterogenous hypoechoic mass in the greater curvature confined to mucosal layer. The acquired specimen displayed characteristics of a high-grade tumor with multiple negative markers (table 1). Therefore, an SS18 FISH test (18q11.2 probe) was performed and the results show the presence of translocation t(X,18) (p11.2;q11.2), consistent with a poorly differentiated synovial sarcoma, a spindle cell monophasic subtype. Completeness of resection of the tumor could not be documented so the patient was referred to surgery for partial gastrectomy of the involved area. The remaining tumor measured 0.7 cm, invaded the submucosal layer but all margins and lymph nodes were uninvolved. A subsequent PET/CT scan did not reveal evidence or residual or metastatic disease.

Discussion: This is the first known case of a primary gastric synovial sarcoma, in a patient of Puerto Rican ethnicity, without family history of genetic disorders, radiation exposure or previous malignancy. Prognosis remains challenging due to the small number of reported cases with surgical resection as the mainstay of treatment. Therefore, it is crucial to continue to identify and diagnose this rare malignancy to better inform treatment and prognostic decisions going forward.




Disclosures:


Javier A. Ortega Balasquide, MD¹, Ubaldo Madera Sanchez, MD², Carlos G. Micames, MD³, Jorge Pelet, MD⁴, Roberto Vendrell, MD². B0707 - A Rare Cause of Upper Gastrointestinal Bleeding: Gastric Synovial Sarcoma, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.