C0531 - Outcomes of Pyogenic Liver Abscess (PLA) on Mortality and Hospitalization Cost Amongst Patients With and Without Cirrhosis: 4-Year Retrospective Study Using National Inpatient Sample (2016 – 2019)

Monday, October 24, 2022

3:00 PM – 5:00 PM ET

Location: Crown Ballroom

Presenting Author(s)

Shiva F. Naidoo, MD

Geisinger Northeast IM Residency Program
Scranton, PA

Shiva Naidoo, MD¹, Sriram B. Chowdary, MD², Dhruv Lowe, MD², Abhinav Goyal, MD², Kishore Kumar, MD², Divey Manocha, MD², Duane Deivert, MD², Soohwan Chun, MD³, Anil Singh, MD⁴, Rahul Dalavai, MBBS³
¹Geisinger Northeast IM Residency Program, Scranton, PA; ²Geisinger Health System, Scranton, PA; ³Geisinger, Scranton, PA; ⁴Geisinger Northeast Program, Scranton, PA

Introduction: Liver abscesses are the most common type of intra-abdominal abscess. Risk factors for developing pyogenic liver abscess include diabetes mellitus, chronic hepatobiliary disease. Limited data is available comparing the clinical outcomes in cirrhotic patients who develop pyogenic liver abscess.

Methods: Using National Inpatient Sample databases from 2016 to 2019, we identified patients presenting with pyogenic liver abscess, the population were then divided based on the presence and absence of cirrhosis using appropriate ICD-10-CM/PCS codes. STATA 17.0 software was used for the analysis. Pearson’s Chi-Square test was used to analyze categorical variable, whereas the student t-test was used to analyze continuous variables. Univariate and multivariate logistic regression was used to adjust for potential confounders. Primary outcome was in hospital mortality due to Pyogenic liver abscess in patients with cirrhosis vs without cirrhosis.

Results: Amongst total of 19,830 patients admitted with pyogenic liver abscess, 1,770 patients had cirrhosis and 18,060 patients did not. Both groups consisted predominantly of white male patients. Mean LOS was 9.47+- 8.17 days in cirrhotic group and 7.18 +- 6.08 in non-cirrhotic group. This difference was statistically significant. Mean total hospitalization charges were $26,845 and $18,347 in the cirrhotic and non-cirrhotic groups respectively. There was no difference in the in-hospital mortality between the groups.

Discussion: Compared to those without cirrhosis, patients with cirrhosis who are admitted with pyogenic liver abscess showed had higher hospital resource utilization in terms of lenght of stay and charges. Though Mortality was higher in PLA with cirrhosis group, the result was not statistically significant

	PLA with cirrhosis, N(%)	PLA without Cirrhosis, N(%)	P value
Total	1770(8.92)	18060(91.70)
Mean age (Years)	60.93±14.23	61.30±15.59
Female(%)	724(40.9)	7404(41)	0.946
Primary Outcome	Odds Ratio	95% Confidence Interval	P value
Mortality(%)	1.673	0.213-13.088	0.624
Secondary Outcomes	Mean	Mean	P Value
Lenght of stay(days)	9.47+/-8.17	7.18+/-6.08	< 0.001
charges(US$)	26845	18347	< 0.001

Table: IN-PATIENT OUTCOME COMPARISON OF CIRRHOTIC PATIENTS PRESENTING WITH PYOGENIC LIVER ABSCESS

Disclosures:

Shiva Naidoo indicated no relevant financial relationships.

Sriram Chowdary indicated no relevant financial relationships.

Dhruv Lowe indicated no relevant financial relationships.

Abhinav Goyal indicated no relevant financial relationships.

Kishore Kumar indicated no relevant financial relationships.

Divey Manocha indicated no relevant financial relationships.

Duane Deivert indicated no relevant financial relationships.

Soohwan Chun indicated no relevant financial relationships.

Anil Singh indicated no relevant financial relationships.

Rahul Dalavai indicated no relevant financial relationships.

Shiva Naidoo, MD¹, Sriram B. Chowdary, MD², Dhruv Lowe, MD², Abhinav Goyal, MD², Kishore Kumar, MD², Divey Manocha, MD², Duane Deivert, MD², Soohwan Chun, MD³, Anil Singh, MD⁴, Rahul Dalavai, MBBS³. C0531 - Outcomes of Pyogenic Liver Abscess (PLA) on Mortality and Hospitalization Cost Amongst Patients With and Without Cirrhosis: 4-Year Retrospective Study Using National Inpatient Sample (2016 – 2019), ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.