Symposia
ADHD - Child
Annabeth Groenman, Ph.D.
Assistant Professor
University of Amsterdam
Amsterdam, Noord-Holland, Netherlands
Annabeth Groenman, Ph.D.
Assistant Professor
University of Amsterdam
Amsterdam, Noord-Holland, Netherlands
Rianne Hornstra,, MSC
psychologist
Accare, Center for Child and Adolescent Psychiatry, University Medical Center
Groningen, Groningen, Netherlands
PAINT- IPDMA collaborators group, none
group author
diverse
netherlands, Flevoland, Netherlands
Marjolein L Luman, PhD
associate professor
VU
Amsterdam, Noord-Holland, Netherlands
Saskia van den oord, PhD
Professor
KU Leuven
Leuven, Oost-Vlaanderen, Belgium
Barbara van den Hoofdakker, Ph.D.
Professor
University of Groningen
Groningen, Groningen, Netherlands
Behavioral interventions, among which behavioral parent training (BPT) are well-established treatments for children with attention-deficit/hyperactivity disorder (ADHD). BPT is based on the hypothesis that improvements in parenting behaviors mediate improvements in children’s behaviors. Although we are aware that behavioral interventions work, they do not work equally for every individual.
Individual participant data meta-analyses (IPDMA) are particularly useful for conducting well powered moderator analyses and therefore highly suitable to determine for which children interventions work. We are the first to conduct an IPDMA on effects and moderators of behavioral interventions for ADHD. During this presentation, we will focus on summarizing the results of the current IPDMA on behavioral and parenting outcomes, reflect on the method IPDMA and share our tips for those who plan to attempt a similar endeavor.
Method: We collected individual participant data of 32 randomized controlled trials into behavioral interventions for ADHD (n>3500) and performed an IPDMA where we examined behavioral outcomes (i.e., ADHD, ODD, CD and impairment). From out database we selected BPT to look at and parenting outcomes (positive and negative parenting). Moreover, relevant moderators for both outcomes were explored.
Results. Behavioral treatment for ADHD leads to an improvement in all mentioned outcomes1. Several significant moderators were detected for behavioral outcomes. We found that single parenthood moderated ODD outcomes. Moreover, we found that higher baseline CD or ADHD symptoms, a CD diagnosis and single parenthood, were related to worse outcomes in the control, but not the intervention group. We are currently running moderator analyses for parenting outcomes and will present these results during ABCT.
Conclusion: Concerning behavioral outcomes of BPT for ADHD, results showed that some groups are more vulnerable for deterioration of their symptoms when these are not treated. This finding shows the potential and power of the IPDMA approach to detect effects that do not arise from moderation analysis from single studies or meta-regressions from meta-analyses.
Further, we will share our tips and tricks for others who attempt to perform a similar study. While IPDMA is a promising approach with great potential, several aspects should be taken into account before attempting such an endeavor.