Project Firstline aims to educate all US health care workers with the foundational understanding of infection prevention and control (IPC) to protect the nation from infectious disease threats, such as COVID-19. The AAP is one of several partners in this initiative. As a Project Firstline partner, the AAP serves as a virtual training center on infection prevention and control. The goal of the center is to expand and strengthen the capacity, collaboration, and coordination of pediatric health care providers during the ongoing response to COVID-19, and to improve the health of all children and their families. This training center will include educational materials, collaborative learning opportunities and clinical practice enhancements.