234 - Efficacy and Safety of Intranasal Dexmedetomidine for Pediatric Sedation Dentistry

Purpose: The purpose was to compare the effectiveness and safety of intranasal dexmedetomidine (DEXNO) with oral midazolam (MIDNO), and oral hydroxyzine/oral midazolam (MIDHYXNO) all with nitrous oxide when used for sedation during pediatric dental procedures.

Methods: This prospective randomized control trial will recruit children ages 3-6 years old who meet the inclusion criteria. Children will be randomized into one of the following drug regimens:  1) intranasal dexmedetomidine, 2) oral midazolam, and 3) oral hydroxyzine with oral midazolam; all combined with N₂O. Effectiveness will be evaluated based on procedure completion and adequate sedation level utilizing a standardized scaled modified by the AAPD. Safety will be assessed by major and minor adverse events.

Results:

Results pending.

Conclusion:

Conclusions cannot be drawn from this study at this time.