365 - Management of patient with NOMID syndrome in the Pediatric Dental Clinic

Management of patient with NOMID  syndrome in the pediatric dental clinic.

Neonatal Onset Multisystem Inflammatory disease (NOMID) is a congenital inflammatory disorder characterized by tissue damage of the nervous system, skin, and joints. It is a subset of hereditary cyropyrinopathies which result due to a mutation in NLRP3 gene. Individuals with NOMID have a skin rash that is present from birth and persists throughout life and can also have chronic aseptic meningitis and a characteristic arthropathy. History of seizures and vomiting resulting due to chronic meningitis presents a specific challenge in the dental management of the pediatric patient with NOMID. This is a case report of a 14-year-old female with NOMID who was treated for severe dental caries at the UNLV pediatric dentistry clinic. The patient had a positive history of seizures and hence was treated in a comprehensive manner under general anesthesia. This report discusses our management protocol for this case and possibly for a standardized protocol for patients with NOMID. To our knowledge, this is the first report of its kind.