144 - Post-Discharge Adverse Effects Following Moderate Sedation

Purpose: The purpose of the study is to report the post-discharge adverse events following moderate sedation with midazolam, meperidine, and hydroxyzine, and in combination, within an 8-hour and 24-hour time period. The secondary objective is to determine the differences in post-discharge adverse events using these different medications.

Methods: The study will recruit approximately 50 children, from ages 24 months to 5 years and 11 months old with ASA I-II status that receive non-IV sedation following standard sedation procedures.  The investigator will call the legal guardian at the 8 hour and 24 hours to follow-up and obtain updated responses from the questionnaire.

Results: Twenty subjects have completed the project between the ages of 2-6, ASA I and II. Ten subjects were lost to follow-up. Due to the sample size, there were no statistical significance between the different variables.  

Conclusion: In comparison between the different ages (2-3 vs. 4-5), and the IM and PO regiments, there does not appear to be any statistical signifiance. Recruitment of more subjects for future comparison is needed to run proper statistical analysis.