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Featured Researcher – Rajan Thakkar, MD
 Featured Researcher – Rajan Thakkar, MD 150 150 Alaina Doklovic
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Rajan K. Thakkar, MD, FACS, is a pediatric surgeon, the Trauma Medical Director, and the co-Director of the Burn Center at Nationwide Children’s Hospital. He is an associate professor of Surgery and Pediatrics at The Ohio State University College of Medicine and is a…

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Toddler playing with toys
Supporting Optimal Developmental Outcomes After Neonatal Opioid Withdrawal Syndrome
 Supporting Optimal Developmental Outcomes After Neonatal Opioid Withdrawal Syndrome 1024 575 Abbie Miller
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Children with prenatal opioid exposure have a higher risk for developmental and behavioral concerns. Prenatal opioid exposure is still far too common. Experts estimate that one infant who has been exposed to opioids is born every 15 minutes in the United States.  While standard…

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Scalable Delivery of Universal Suicide Prevention in Schools
 Scalable Delivery of Universal Suicide Prevention in Schools 1024 657 Pam Georgiana
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Implementing the Signs of Suicide (SOS) Prevention and Screening Program   Suicide is the second-leading cause of death among youth ages 10 to 19 years, and data indicate no sign of it decreasing as a major public health issue. While acute care and crisis…

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Infliximab Biosimilars Improve Growth Outcomes in Children With Inflammatory Bowel Disease
 Infliximab Biosimilars Improve Growth Outcomes in Children With Inflammatory Bowel Disease 1024 683 Mary Bates, PhD
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Treatment with either the infliximab originator or a biosimilar improves clinical and growth outcomes. In a new study, researchers at Nationwide Children’s Hospital report that children with inflammatory bowel disease showed similar growth and clinical outcomes whether they were treated with the infliximab originator…

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New Approach to Understanding Slow Oscillations in the Sleeping Brain
 New Approach to Understanding Slow Oscillations in the Sleeping Brain 150 150 Jessica Nye, PhD
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Investigators have proposed a novel model-based approach that leverages data generated during sleep to mimic global slow oscillations in the sleeping brain with closed-loop (cl) Transcranial Alternating Current Stimulation (tACS). “We’re really interested in the sleeping brain because as we develop, the brain is…

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Black and white image of teen girl posing outside
Integrating PCOS Research and Clinical Care for Adolescents
 Integrating PCOS Research and Clinical Care for Adolescents 1024 575 Pam Georgiana
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Researchers at Nationwide Children’s are participating in building the first-ever national registry of adolescent Polycystic Ovary Syndrome (PCOS) patient data through a National Institutes of Health (NIH)-funded research grant. The grant will collect patient data from more than 12 multidisciplinary PCOS clinics, including Nationwide…

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How Are Insulin Pumps Being Utilized for Patients with Type 1 Diabetes?
 How Are Insulin Pumps Being Utilized for Patients with Type 1 Diabetes? 1024 683 Pam Georgiana
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A multicenter observational study of 22,000 children and adults shows improving quality of life for patients with type 1 diabetes.    Type 1 diabetes diagnoses are increasing among children, particularly those in racial/ethnic minority groups. New technology, specifically insulin pumps and continuous glucose monitoring…

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What Features Make Virtual Reality Effective in Pain Management?
 What Features Make Virtual Reality Effective in Pain Management? 934 401 Mary Bates, PhD
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Game realism, fun and engagement all impact pain perception during burn dressing changes. Researchers from Nationwide Children’s Hospital show that three key features of a virtual reality intervention (game realism, fun and engagement) influence self-reported pain scores during burn dressing changes. The findings provide…

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Spinal Anesthesia – an Alternative for Infants Undergoing Surgery
 Spinal Anesthesia – an Alternative for Infants Undergoing Surgery 1024 683 Pam Georgiana
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A new study highlights the safety and efficacy of more than 1,000 surgeries using spinal anesthesia. Nationwide Children’s Infant Spinal Anesthesia Program, headed by Grant J. Heydinger, MD, a pediatric attending anesthesiologist in the Department of Anesthesiology & Pain Medicine, recently published the results…

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Quality Improvement Approach Reduces Pediatric Asthma Emergency Department Visits by 33%
 Quality Improvement Approach Reduces Pediatric Asthma Emergency Department Visits by 33% 770 513 JoAnna Pendergrass, DVM
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With institutional support, a primary care-based quality improvement initiative markedly reduced asthma-related emergency department visits for children with asthma. Researchers at Nationwide Children’s Hospital implemented a quality improvement (QI) project that reduced pediatric asthma emergency department (ED) visits by 33% from 2010 to 2019.…

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Improving UTI Detection in Neonates: Antimicrobial Peptides and Cotton Balls
 Improving UTI Detection in Neonates: Antimicrobial Peptides and Cotton Balls 1024 683 Katie Brind'Amour, PhD, MS, CHES
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New research sets the stage for less-invasive urinary tract infection identification in neonates 22-37 weeks gestational age. A team of researchers driving the revolution in urinary tract infection (UTI) identification using antimicrobial peptides (AMPs) has now expanded their focus from adults and children to…

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Novel Immunotherapy Approach Enhances Immune Surveillance in Gliomas
 Novel Immunotherapy Approach Enhances Immune Surveillance in Gliomas 1024 575 Lauren Dembeck
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Genetically engineered myeloid cells release interleukin-2, which helps the immune system overcome the immunosuppressive tumor microenvironment in gliomas.   Gliomas — tumors originating from the neuronal support (glial) cells of the central nervous system — are one of the leading causes of cancer-related death…

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Modulator Therapy Improves Chronic Sinus Disease in Individuals with Cystic Fibrosis
 Modulator Therapy Improves Chronic Sinus Disease in Individuals with Cystic Fibrosis 1024 683 Mary Bates, PhD
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Following 1 year of therapy, patients showed improved sinus CT metrics and clinical outcomes. Over the last decade, the development of cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs has revolutionized the treatment of cystic fibrosis (CF). The most widely used modulator is the…

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What Pulmonologists Need to Know About Respiratory Insufficiency in Neuromuscular Disease
 What Pulmonologists Need to Know About Respiratory Insufficiency in Neuromuscular Disease 600 400 Katie Brind'Amour, PhD, MS, CHES
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The RIND Study Group has released new consensus criteria to proactively identify hypoventilation in children with neuromuscular diseases. Recently released consensus criteria from an expert panel of pediatric pulmonologists and sleep specialists define and provide diagnosis guidance surrounding respiratory insufficiency in neuromuscular disease (RIND).…

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Featured Researcher – Elaine Mardis, PhD
 Featured Researcher – Elaine Mardis, PhD 150 150 Alaina Doklovic
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Elaine Mardis, PhD is co-Executive Director of the Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital and holds the Rasmussen Nationwide Foundation Endowed Chair in Genomic Medicine. She is also a Professor of Pediatrics at The Ohio State University…

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At the Heart of a First R01 Grant
 At the Heart of a First R01 Grant 150 150 Alaina Doklovic
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Allison Bradbury, MS, PhD, is a principal investigator in the Center for Gene Therapy at Nationwide Children’s Hospital and an assistant professor in the Department of Pediatrics at The Ohio State University. She recently received her first R01 grant to develop novel therapeutic strategies…

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Clinical Trial Shows Promising Results for AAV Gene Therapy for LGMD 2E/R4
 Clinical Trial Shows Promising Results for AAV Gene Therapy for LGMD 2E/R4 1024 783 Abbie Miller
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Recently published in Nature Medicine, interim results from a Phase 1/2 trial offer promising results.   Limb-girdle muscular dystrophy (LGMD) 2E/R4 is a rare, progressive neuromuscular disorder caused by mutations in the β-sarcoglycan (SGCB) gene. These mutations lead to SGCB protein deficiency, ultimately resulting…

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Dr. Jayanthi standing in OR
When Surgery Does Not Go as Planned
 When Surgery Does Not Go as Planned 1024 575 V. Rama Jayanthi, MD
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A surgeon’s reflections on complications, trust and moving forward together.   I have been thinking back on my career and the instances where a patient developed a complication, and the surgery did not go as planned. Having a family state their child was better…

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Dr. Iobst with patient
Magnetically Controlled Limb Lengthening Devices Safe for Patients With Programmable Implantable Devices, Study Shows
 Magnetically Controlled Limb Lengthening Devices Safe for Patients With Programmable Implantable Devices, Study Shows 1024 683 Erin Gregory
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Recent study evaluated the safety and efficacy of using magnetically controlled intramedullary nails in patients with programmable implantable devices, shedding light on a previously unexplored area of orthopedic surgery. In a pivotal study published in the Strategies in Trauma and Limb Reconstruction, led by…

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Addressing Gastrointestinal Disorders to Improve Quality of Life for Individuals With Down Syndrome
 Addressing Gastrointestinal Disorders to Improve Quality of Life for Individuals With Down Syndrome 1024 661 Erin Gregory
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Down syndrome (DS) affects approximately 1 in 700 children born in the United States, presenting with intellectual disability and distinct physical features. Alongside these challenges, individuals with DS often contend with various medical issues that impact their quality of life (QoL), including gastrointestinal (GI)…

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