There’s also the inactive form of the molecule, known as cis isomers. Their shape differs substantially from that of the all-trans form. Because of this, cis isomers may not fit where they are supposed to, leaving K2-dependent proteins inactivated.
The US Pharmacopeia monograph requires a content of >98% all-trans. However, determination in finished supplements rarely happens, allowing low-quality products to enter the market and under-perform in K2 efficacy. The problem is you can’t see it on the label. In fact, consumer product testing consistently demonstrates unacceptably high numbers of MK-7 products containing high concentrations of the biologically inactive cis form of vitamin K2.⁽¹⁾ This means K2-dependent proteins are left inactivated, and so consumers won’t get the benefits they need and paid for. That’s why we want to join with you in taking a stand for great K2.