Assays Drug Discovery Fluorescence Assays HTS Products & Services Reagents

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PerkinElmer | Cisbio has been pushing GPCR investigation forward for many years, regularly creating cutting-edge assays and technologies to characterize receptors and screen compounds, and to optimize leads. During the SLAS 2021 event, we will be proud to announce the release of several highly anticipated assays. These assays will open new doors to help GPCR research take another big step forward. These assays will be announced on January 25, 2021. Ligand binding is the very first step in the GPCR signaling process. Running binding assays enables researchers to assess the tightness of the drug-GPCR interaction. With Tag-Lite, PerkinElmer | Cisbio offer an easy-to-use technology allowing researchers to investigate efficiently with no radioactive ligand- GPCR interaction. This binding step is generally followed by the recruitment of one of the many classes of G proteins. PerkinElmer | Cisbio offers multiple assays across different technologies to cover Gs and Gi classes, notably thanks to cAMP based assays. In addition, for Gq-coupled GPCR, an innovative approach is available with the IP-One assay. This assay has been shown to offer superior benefits over traditional calcium flux assays. GPCR activation frequently leads to the phosphorylation of very specific proteins inside cells. ERK, AKT, MEK, and CREB are some examples of proteins that become phosphorylated as a result of GPCR activation, but hundreds of other proteins are potentially under GPCR control. Alpha and HTRF technologies stand as the most effective alternatives to Western Blot and ELISA assays for measuring protein phosphorylation. For research use only. Not for use in diagnostic procedures.

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