HTS Products & Services
Transcreener cGAMP cGAS Assay - New TR-FRET Readout
The Transcreener cGAMP cGAS Assay directly measures cyclic GMP-AMP (cGAMP) produced by cyclic GMP-AMP synthase (cGAS, C6orf150, 2'3'-cGAMP Synthase). By measuring the production of cGAMP researchers can effectively determine the activity of the cGAS enzyme. The assay provides a powerful tool to screen entire compound libraries for cGAS modulators to help find new therapeutics targeting the cGAS-STING pathway.
Applications include: Measure Enzymatic Activity of cGAS, Screen Compound Libraries for cGAS inhibitors, Quantify Inhibitor Potency, Determine Inhibitor-cGAS Residence Time.
Features Include: Direct detection of unlabeled cGAMP, Easy to use, homogenous, one-step format, Robust Assay Z’ > 0.7 under initial velocity conditions, Far-red fluorescent readouts minimize compound interference, A safe, non-radioactive method, Available in FP or TR-FRET readouts.