Assay Development Drug Discovery Proteomics

Protein Degraders and Lead Discovery Tools

MilliporeSigma

Targeted protein degradation is an emerging drug discovery strategy for accessing difficult-to-treat diseases. While traditional small-molecule or antibody drugs may only allow access to ~20% of the proteome, degradation techniques may open the door to the other 80%. The molecules used in these approaches are called protein degraders, such as proteolysis targeting chimeras (PROTACs), bifunctional molecules that eliminate target proteins from cells. Our newest Protein Degraders and Lead Discovery Tools include degraders and tool compounds for validation, assay development, and screening for protein-binding ligands and complement our protein degrader building blocks for synthesis of protein degraders.

Other product: LightOx PhotoReact 365






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