Associate Professor of Dermatology Yale University School of Medicine Yale University School of Medicine fairfield, Connecticut
Alopecia areata (AA) is a common autoimmune disease characterized by non-scarring hair loss that may be disfiguring. The lifetime prevalence of AA is approximately 2%. Comorbid autoimmune disease is common in AA patients, with thyroid disorders being the most frequently described conditions, eg. Hashimoto’s thyroiditis and Graves’ disease. Similarly, there is an association with atopy (atopic dermatitis, asthma, allergic rhinitis). There is significant negative impact of AA on quality of life. Recently, there have been tremendous advances in understanding disease pathogenesis, demonstrating T-cell mediated damage to hair follicles involving interferon-gamma and interleukin-15, which has led to the development of Janus kinase inhibitor treatment of AA. In this presentation, these and other aspects of AA and its treatment will be discussed.