Undergraduate Research Assistant University of Texas at El Paso El Paso, Texas, United States
Luca Henze (University of Texas at El Paso)| Jessica Hess (University of Texas at El Paso)| Denisse Gutierrez (University of Texas at El Paso)| Armando Varela-Ramirez (University of Texas at El Paso)| Renato Aguilera (University of Texas at El Paso)
Using high-throughput chemical library screening for novel therapeutic candidates, a thienopyrazole derivative was identified with cancer-selective cytotoxic effects. This compound exhibited effective and consistent cytotoxicity against a range of human cancer cell lines at nanomolar to low micromolar concentrations after 48 hours of treatment. Subsequent analyses by flow cytometry and other cellular assays demonstrated a dose-dependent apoptotic cell death, cell cycle interference and inhibition of microtubule polymerization. These results merit the further analysis of this compound as a therapeutic treatment of human cancer, specifically those of hematopoietic and cervical origin.