MSc. candidate Memorial University of Newfoundland, Newfoundland and Labrador, Canada
Sayi'Mone Tati (Memorial University of Newfoundland)| Laleh Alisaraie (Memorial University of Newfoundland)
Dynein is a motor protein that carries cargoes in eukaryotic cells from the periphery to the nucleus. Studies have shown that dynein is involved in some medical conditions such as cancer and neurodegenerative diseases (e.g. Huntington’s, Parkinson, and Alzheimer’s disease). Due to the gigantic size of dynein (1.5 MDa) and its velocity (1 µm/s), studying the protein has presented challenges. However, some small-molecule inhibitors are thought to be suitable for studying the mechanism of dynein. Chemical compounds with inhibitory effects proposed by other research groups, have yet unknown features, such as their binding sites as well as their binding profiles with respect to the domains of dynein. The aim of this study is to explore how the inhibitors bind to dynein, so that it could provide insights into the mechanism of how the motor domain of dynein accomplishes its functions. That will provide clues on how to design novel inhibitors or analogues of the inhibitors with the purpose of finding potential drugs for the treatment of diseases involving dynein activity.