UT Health San Antonio
Dr. Archer’s interest in membrane proteins and ion channels brought her to UTHSCSA in 2011, where she applied biochemical chemical analyses and structural biology methods to improve the understanding of the molecular mechanism of a potassium ion channel. She earned her PhD in Biochemistry, in June 2017, and soon afterward, joined Dr. Jim Stockand’s laboratory at UTHSCSA as a postdoctoral researcher. Her current focus is to understand the molecular mechanisms of how minor plasma membrane phospholipids regulate ENaC (Epithelial Na+ Channel) function. ENaC is an ion channel that is critical for the transport of Na+ and filtered fluid reabsorption through the epithelial lining of many tissues, such as the lungs and kidney. The Stockand Lab used mutagenesis to show that the amino terminus of the beta and gamma subunits contain sites rich in basic residues that may directly bind to these phospholipids. Dr. Archer recently described two binding sites on ENaC with moderate affinity. She is currently investigating the avidity and cooperativity of PIP2 binding with multiple sites on ENaC using optogenetics, electrophysiology, and structural biology methods utilizing purified protein fragments.