Session: Specialized Pro-Resolving Mediators (SPMs) and Their Role in Actively Resolve Inflammation: Physiological Mechanisms and Immune-Nutrition Solutions for the Increasing Challenge of Inflammatory Health Conditions (Sponsored Satellite Program)
Results After SPM Supplementation in Human Patients – A New Immune-Nutrition Therapeutic Approach (Sponsored Satellite Program)
CEO Azur Global Nutrition Winston-Salem, North Carolina, United States
Disclosure: Azur Global Nutrition: Employee
The lack of production of SPMs from its precursors (namely EPA and DHA) can decrease the resolution process.
Oral supplementation of SPMs has been suggested to increase SPMs levels to contribute to the resolution of inflammation process.
This supplementation with SPMs has already been evaluated in healthy human volunteers, patients with nutritional imbalances associated with peripheral cardiovascular diseases and subjects with chronic pain.
SPMs oral supplementation increases in the levels of SPMs in the blood, which is correlated with a modulation of the immune system and an improvement in some biomarkers and clinical parameters of the study target population.
Access to this session’s recordings are available on ASN on Demand as open access.
Inflammation, specifically unresolved or uncontrolled inflammation, is widely recognized as a critical component of 75% of human chronic diseases, including CVD, atherosclerosis, metabolic syndrome, cancer, osteoarticular health or infection, like the one we are witnessing because of SARS-CoV-2.
Recent research has led to a greater understanding of the acute inflammatory response and the essential role of “specialized pro-resolving mediators” (SPMs) in actively resolving inflammation. SPMs are the active metabolites from EPA and DHA biosynthesized endogenously and are involved in the body’s normal physiological pathways of inflammation, restoring the tissue environment to its normal condition after immune activation and positively influencing infection, pain and tissue and organ protection.
During the session we will review the physiological mechanisms that determine the active termination or resolution of the inflammatory response together with the role of SPMs, and we will discuss the latest knowledge on Covid-19 infectious inflammation as well as the recent data published in humans after SPM supplementation.