Metabolic function is significantly impaired in paraplegic and tetraplegic women and men, and impaired glucose and lipid metabolism are more prevalent in the spinal cord injury (SCI) population than in the general population. Accumulating evidence from able-bodied individuals demonstrates that gut microbiota (the ecological community of commensal, symbiotic, and pathogenic microorganisms in the gastrointestinal [GI] tract) and metabolic health are linked. For example, human fecal transplants have demonstrated transferability of insulin-sensitive phenotypes in the able-bodied population. In this symposium we will discuss current evidence on a potential link between microbiome composition and metabolic health in SCI and demonstrate results from our research studies which compared the gut microbiome composition and serum metabolome profile among individuals with SCI and normal glucose tolerance (NGT) or prediabetes/type 2 diabetes (P/DM).
Describe the effect of SCI on gut motility
Define gut dysbiosis and describe its effects on metabolic health and bowel function
Describe gut-derived metabolites and their effects on metabolic health
Demonstrate findings from microbiome studies comparing the gut microbiome composition and serum metabolome profile among individuals with SCI and normal glucose tolerance (NGT) or prediabetes/type 2 diabetes (P/DM)