University of Kentucky Bowling Green, KY, United States
Hassnain Syed, MD1, Anastasia Schuldt, 2, Suman Shekar, MD3, Avinash Aravantagi, MD4 1University of Kentucky, Bowling Green, KY; 2UK College of Medicine - Bowling Green, Bowling Green, KY; 3UK College of Medicine - Medical Center Bowling Green, Bowling Green, KY; 4UK College of Medicine - Medical Center Bowling Green, Bowling green, KY
Introduction: Eosinophilic esophagitis (EoE) is becoming an increasingly recognized disease present in 0.4% of the population. Through retrospective chart examination, we sought to establish any significant correlation between social history, symptomatology, and diagnosis of EoE in the south-central Kentucky population. Social history included reported use of tobacco, alcohol, and marijuana. We limited our population to those patients who received esophageal biopsy as this is the gold standard for eosinophilic esophagitis diagnosis.
Methods: We queried the pathology records from the Medical Center Bowling Green, a 337 bed regional hospital in south-central Kentucky, for patients who had obtained esophageal biopsy from January 2013 through June 2019, totaling 55 patients. We individually reviewed patient charts to obtain data including biopsy diagnosis, demographics such as sex and age at biopsy, presenting symptom, and any recorded social including use of alcohol, tobacco, and marijuana. Biopsy diagnosis groups consisted of eosinophilic esophagitis (EoE), no histopathologic change, and reflux esophagitis. Between our three diagnosis groups, Chi-squared test was used to compare presenting symptom and social history. One-way ANOVA test was used to analyze mean and variance in age among diagnosis groups with two-way t-test to compare between group pairs.
Results: Mean age for patients diagnosed with EoE, no histopathologic change, and reflux esophagitis was 37.3, 52.2, and 52.7 years, respectively. Patients presenting with EoE were significantly younger than patients in either no histopathologic change (p=0.017) or reflux esophagitis (p=0.034) (ANOVA p = 0.014). There was no significant difference in age between patients with reflux esophagitis and no histopathologic change (p=0.96). Of 55 total patients, 24 (44%) were male and 31 (56%) female; of patients diagnosed with EoE, 19 (48%) were male and 21 (52%) female, amounting to no significant link between sex and EoE in our study population (p=0.067).
Discussion: Based on prior studies, we predicted that EoE would be associated with younger age, male sex, dysphagia on presentation, and alcohol use, with EoE less common in smokers. As expected, EoE correlated to younger age at presentation (mean age 37.3, p=0.0135). Interestingly, this was the only statistically significant finding. In our population, EoE was not significantly associated with sex, presenting symptomology, or social history (tobacco, alcohol, marijuana).
Disclosures: Hassnain Syed indicated no relevant financial relationships. Anastasia Schuldt indicated no relevant financial relationships. Suman Shekar indicated no relevant financial relationships. Avinash Aravantagi indicated no relevant financial relationships.
Hassnain Syed, MD1, Anastasia Schuldt, 2, Suman Shekar, MD3, Avinash Aravantagi, MD4. P2383 - Assessing the Influence of Tobacco, Alcohol, and Marijuana on the Development of Eosinophilic Esophagitis, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.