P0740 - Diagnostic Yield of Endoscopic Ultrasound-Guided Liver Biopsy in Comparison to Percutaneous Liver Biopsy: A Two Center Experience

Daryl Ramai, MD, MSc¹, Antonio Facciorusso, MD, PhD², Maria Bellocchi, MD³, Laura Bernardoni, MD³, Erminia Manfrin, MD⁴, Nicola Muscatiello, MD⁵, Stefano Crinò, MD^3
1University of Utah, Salt Lake City, UT; ²University of Foggia, Foggia, Puglia, Italy; ³University Hospital of Verona, Verona, Veneto, Italy; ⁴Rossi University Hospital, Verona, Veneto, Italy; ⁵Ospedali Riuniti di Foggia, Foggia, Puglia, Italy

Introduction: There is scarce and conflicting evidence on the comparison between endoscopic ultrasound (EUS) and percutaneous (PC)-guided liver biopsy (LB). Aim of this study was to compare the two approaches in a series of patients with parenchymal and focal liver lesions.

Methods: Fifty-four patients undergoing EUS-LB in two high-volume centers between 2017 and 2021 were compared to 62 patients who underwent PC-LB. Primary outcome was diagnostic adequacy rate. Secondary outcomes were diagnostic accuracy, total sample length (TSL), number of complete portal tracts (CPTs), procedural duration and adverse events. Variables were compared using the Chi-square and Mann-Whitney test.

Results: Median age was 56 years (interquartile range 48-69) in EUS-LB group and 54 years (45-67) in PC-LB group and most patients were male. Indication to LB was due to parenchymal disease in 50% of patients whereas the other patients underwent LB due to focal liver lesions.

Diagnostic adequacy was 100% in PC-LB and 94.4% in EUS-LB group (p=0.74), whereas diagnostic accuracy was 88.8% in the EUS-LB group and 100% in the PC-LB (p=0.82). Median TSL was significantly greater in the PC-LB group (27.4 mm, IQR 21-29) as compared to the EUS-LB group (18.5 mm, 10.1-22.4; p=0.02). Number of complete portal tracts was 21 (11-24) in the PC-LB group and 18.5 (10-23.2) in EUS-LB group (p=0.09). EUS-LB was a significantly longer procedure (7 minutes, 5-11 versus 1 minute, 1-3 of PC-LB; p< 0.001) and no evidence of adverse events was observed in any of the study groups. These results were confirmed in the subgroup analysis performed according to the indication to LB (parenchymal disease versus focal lesion).

Discussion: Our analysis demonstrates that EUS-LB and PC-LB are comparable in terms of diagnostic accuracy in patients with parenchymal liver disease and focal liver lesions.

Table: Study outcomes comparing EUS-guided liver biopsy and percutaneous liver biopsy


Disclosures:
Daryl Ramai indicated no relevant financial relationships.
Antonio Facciorusso indicated no relevant financial relationships.
Maria Bellocchi indicated no relevant financial relationships.
Laura Bernardoni indicated no relevant financial relationships.
Erminia Manfrin indicated no relevant financial relationships.
Nicola Muscatiello indicated no relevant financial relationships.
Stefano Crinò indicated no relevant financial relationships.


Daryl Ramai, MD, MSc¹, Antonio Facciorusso, MD, PhD², Maria Bellocchi, MD³, Laura Bernardoni, MD³, Erminia Manfrin, MD⁴, Nicola Muscatiello, MD⁵, Stefano Crinò, MD³. P0740 - Diagnostic Yield of Endoscopic Ultrasound-Guided Liver Biopsy in Comparison to Percutaneous Liver Biopsy: A Two Center Experience, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.