St. Joseph's Hospital and Medical Center, Creighton University School of Medicine Phoenix, AZ, United States
Bianca Varda, MD1, Anna Cramer, FNP1, Zaid Ansari, MD2, Brett Hughes, MD3, Shifat Ahmed, MD1 1St. Joseph's Hospital and Medical Center, Creighton University School of Medicine, Phoenix, AZ; 2Creighton University School of Medicine Phoenix Program, Phoenix, AZ; 3Creighton University/St. Joseph's Medical Center, Phoenix, AZ
Introduction: Isolated large intestinal involvement of neurofibromatosis is a fairly rare clinical finding. Herein, we present a case of colonic ganglioneuromas causing pseudo-obstruction in a patient with neurofibromatosis without other gastrointestinal tract findings.
Case Description/Methods: A 59-year-old male with a history of neurofibromatosis and gastroesophageal reflux disease (GERD) on pantoprazole presented to our clinic for a follow-up visit. Despite medical management, he reported worsening of his GERD symptoms, namely epigastric pain and bloating. He was scheduled for surveillance esophagogastroduodenoscopy (EGD) and colonoscopy for colon cancer screening. On the morning of the procedure, he was afebrile and vital signs were stable upon arrival. EGD showed gastritis, but was otherwise unremarkable. Colonoscopy revealed a ~7cm pedunculated polyp in the ascending colon and a 4cm flat polyp and 1 pedunculated polyp in the transverse colon. Pathology from the polyps showed submucosal lipomas as well as ganglioneuroma with associated acute colonic ulceration. Due to the size and location of the ascending colon polyp, it was thought to be contributing to his symptoms of obstruction. At a recent clinic follow-up visit, he was doing well and endorsed improvement in his reflux, bloating, and epigastric pain. He was also having regular bowel movements and denied constipation. The patient was scheduled for repeat surveillance colonoscopy to be performed in 2 years.
Figure: ~7cm pedunculated polyp in the ascending colon
Disclosures: Bianca Varda indicated no relevant financial relationships. Anna Cramer indicated no relevant financial relationships. Zaid Ansari indicated no relevant financial relationships. Brett Hughes indicated no relevant financial relationships. Shifat Ahmed indicated no relevant financial relationships.
Bianca Varda, MD1, Anna Cramer, FNP1, Zaid Ansari, MD2, Brett Hughes, MD3, Shifat Ahmed, MD1. P0167 - A Rare Presentation of Isolated Colonic Polyps Causing Pseudo-Obstruction in a Patient With Neurofibromatosis, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.