P1063 - Clinical Characteristics and Outcomes in African American Patients With Acute Pancreatitis

Ishani Shah, MD¹, William Yakah, BS¹, Awais Ahmed, MD¹, Supisara Tintara, MD¹, Cristina Sorrento, MD¹, Cinthana Kandasamy, MD¹, Steven D. Freedman, MD, PhD¹, Darshan J. Kothari, MD², Sunil G. Sheth, MD^1
1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; ²Duke University Medical Center, Durham, NC

Introduction: Acute pancreatitis (AP) is a highly inflammatory state that is associated with significant morbidity and mortality. There is limited data on the natural history of AP in African American (AA) patients. The aim of our study was to assess the disease characteristics and outcomes in AA patients with AP and compare with non-AA patients.

Methods: We retrospectively analyzed patients with a confirmed diagnosis of AP admitted to our institution from 2008-2018. We compared demographic characteristics, comorbidities, severity of AP and outcomes of AP between AA and non-AA patients. Continuous variables were represented as means and standard deviations. These were compared between the study and control groups using the t-test or Wilcoxon rank-sum test, as deemed appropriate. Categorical variables were represented as frequencies (percentage) and analyzed using the 2-way chi-square test to compare the 2 groups. Statistical significance was assigned at 0.05.

Results: Out of 878 patients with AP, 187 patients were of AA ethnicity. Apart from a higher proportion of AA patients being men (58.3% vs 49.4%; p=0.03), there were no significant differences between groups (Table 1). Alcohol was a significantly higher cause for AP in AA patients (31.2% vs 17.4%, p=0.013) who also had greater use of alcohol (45.5%vs 34.2%, p=0.006) and tobacco ((38.5% vs 24.6%, p< 0.001). A higher proportion of AA patients had mild disease (83.4% vs 73.7%, p=0.004). The average time to refeeding was significantly shorter in AA patients (1.89±2.39 vs 2.38±2.50 days; p=0.016). There were no other significant differences in patient outcomes (Table).

Discussion: Although some demographic and clinical features of AA patients with AP differ from non-AA patients, there is no difference in outcomes including length of stay, ICU stay, mortality and readmissions in AA patients compared to other ethnicities. Further work is needed to identify areas of healthcare disparities that may exist in management patients of different ethnicities.

	African Americans (n=187)	Non-African Americans (n=690)	p-value
DEMOGRAPHIC CHARACTERISTICS
Mean age (SD)	52.3 (14.6)	52.3 (16.5)	0.944
Male gender	109 (58.3%)	341 (49.4%)	0.038
Mean BMI (SD)	27.5 (7.56)	27.2 (6.57)	0.667
ETIOLOGY			0.013
Gallstones	47 (25.3%)	186 (27%)
Alcohol	58 (31.2%)	120 (17.4%)
Post-ERCP	3 (1.61%)	24 (3.49%)
Idiopathic	61 (32.8%)	274 (39.8%)
Mass	10 (5.38%)	40 (5.81%)
Drug-induced	6 (3.23%)	25 (3.63%)
CF	1 (0.54%)	12 (1.74%)
SEVERITY			0.004
Mild	156 (83.4%)	506 (73.7%)
Moderate	22 (11.8%)	156 (22.7%)
Severe	9 (4.81%)	25 (3.64%)
SUBSTANCE ABUSE
Alcohol use	85 (45.5%)	236 (34.2%)	0.006
Tobacco use	72 (38.5%)	169 (24.6%)	< 0.001
OUTCOMES
Mean number of days to refeeding (SD)	1.89 (2.39)	2.38 (2.50)	0.016
ICU admission	12 (6.42%)	36 (5.22%)	0.647
Mean LOS in days (SD)	5.08 (5.12)	5.74 (6.75)	0.151
Inpatient mortality	0	8 (1.16%)	0.214
One-year mortality	6 (3.21%)	17 (2.47%)	0.051
30-day readmission	39 (20.9%)	149 (21.7%)	0.877

Table: Comparison of demographic characteristics, comorbidities and outcomes between African American and non-African American patients with acute pancreatitis


Disclosures:
Ishani Shah indicated no relevant financial relationships.
William Yakah indicated no relevant financial relationships.
Awais Ahmed indicated no relevant financial relationships.
Supisara Tintara indicated no relevant financial relationships.
Cristina Sorrento indicated no relevant financial relationships.
Cinthana Kandasamy indicated no relevant financial relationships.
Steven Freedman indicated no relevant financial relationships.
Darshan Kothari indicated no relevant financial relationships.
Sunil Sheth indicated no relevant financial relationships.


Ishani Shah, MD¹, William Yakah, BS¹, Awais Ahmed, MD¹, Supisara Tintara, MD¹, Cristina Sorrento, MD¹, Cinthana Kandasamy, MD¹, Steven D. Freedman, MD, PhD¹, Darshan J. Kothari, MD², Sunil G. Sheth, MD¹. P1063 - Clinical Characteristics and Outcomes in African American Patients With Acute Pancreatitis, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.