P1126 - Gastric Outlet Obstruction Secondary to Intrapapillary Mucinous Neoplasm

Michael Beattie, DO¹, Brandon T. Wiggins, DO, MPH², Mark Rigsby, ³, Mark J. Minaudo, DO^2
1Genesys Regional Medical Center, Holly, MI; ²Ascension Genesys Hospital, Grand Blanc, MI; ³Genesys Regional Medical Center, Grand Blanc, MI

Introduction: An 85-year-old male presented to the hospital with nausea and vomiting after eating dinner the previous night. Upon endoscopic evaluation, he was found to have gastric outlet obstruction (GOO) secondary to intrapapillary mucinous neoplasm (IPMN).





Case Description/Methods: An 85-year-old male presented to the hospital with nausea and vomiting after eating dinner the previous night.

A CT scan showed a complex cystic pancreatic head and tail mass of 3.1 cm and 5.7 cm respectively with concern of cystic pancreatic lesions leading to partial GOO (Images 1A).

He underwent esophagogastroscopy on day one of admission which revealed solid and liquid food throughout the esophagus and stomach as well as pyloric stricture. The food was removed and pyloric stricture dilation was attempted with 8 mm CRE balloon. He continued to have trouble tolerating diet. A repeat EGD was performed on day 5. The pylorus was traversed utilizing a neonatal upper endoscope. Mucoid type liquid was present in the duodenum and abnormal mucosa located on the posterior wall which was biopsied and revealed superficial strips of columnar mucosa with basal orientated nuclei and mucinous change confirming our suspicion of GOO secondary to IPMN (Image 1B-D). The patient was discharged to outpatient hospice care on a full liquid diet.

Discussion: IPMNs are rare, with only 2.04 cases per 100,000 person year1 Unlike pancreatic adenocarcinoma where GOO has been shown to occur in up to 20% of cases, to our knowledge there is only one other case of IPMN causing GOO.2,11



IPMN’s are at risk for malignant transformation if they involve the main pancreatic duct, have presence of jaundice or obstruction, greater than 3 cm and/or they have a solid component to the cyst.4,5 The four subtypes include gastric, pancreaticobiliary, intestinal, and oncocytic. Our patient’s pathologic findings were most consistent with gastric type.



Incidence of IPMN has increased since the 1970’s likely due to improved imaging modalities.6 Malignant IPMNs have decreased in frequency as more patients are diagnosed at local stages.7 Diagnosis usually requires MRI or pancreas dedicated CT. Local invasion predominantly occurs in the biliary ducts or the duodenum.8-10 In our review, duodenal invasion has not been reported to be severe enough to lead to GOO.



This case serves as a reminder of the importance of surveillance of pancreatic cystic neoplasms, and the complications that can occur in the absence of surveillance.


Figure: Image 1A - CT showing complex cystic pancreatic head mass with gastric outlet obstruction EGD showing high grade pyloric
Image 1B – EGD showing high grade pyloric stricture Image 1C – EGD showing mucoid liquid in the duodenal bulb Image 1D – Histology of duodenal bulb biopsies revealing superficial strips of columnar mucosa with basal orientated nuclei and mucinous change consistent with gastric type IPMN


Disclosures:
Michael Beattie indicated no relevant financial relationships.
Brandon Wiggins indicated no relevant financial relationships.
Mark Rigsby indicated no relevant financial relationships.
Mark Minaudo indicated no relevant financial relationships.


Michael Beattie, DO¹, Brandon T. Wiggins, DO, MPH², Mark Rigsby, ³, Mark J. Minaudo, DO². P1126 - Gastric Outlet Obstruction Secondary to Intrapapillary Mucinous Neoplasm, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.