P1183 - Most Common Causes of Gastrointestinal Hospitalization in Patients With Cystic Fibrosis

Claire Caplan, MS, BA¹, Colin Wikholm, BS², Akram I. Ahmad, MBBS³, Ioannis Pothoulakis, MD⁴, Loveleen Bhogal, MBBS⁵, Abhinav Sehgal, ², Jang Cho, BA⁶, Sarah Schumacher, BS², Jennie Zhang, DO^4
1Georgetown University School of Medicine, McLean, VA; ²Georgetown University School of Medicine, Washington, DC; ³Medstar Washington Hospital Center, Washington, DC; ⁴MedStar Washington Hospital Center, Washington, DC; ⁵MedStar Washington Hospital Cetner, Washington, DC; ⁶Georgetown University Hospital, Washington, DC

Introduction: Improved survival of cystic fibrosis (CF) has shifted consideration to non-pulmonary complications of the disease, such as gastrointestinal (GI) complications that require hospitalization. We are presenting the most common GI causes of hospitalization in CF patients.

Methods: Patients were included in the study if they had a primary or secondary ICD-10 diagnosis of CF (E84.x). They were captured using major diagnostic categories (MDC06: Diseases and Disorders of the Digestive System, or MDC07: Diseases and Disorders of the Hepatobiliary System and Pancreas). Frequency rank procedures of diagnostic related codes (DRGs) and primary ICD-10 diagnoses identified the most common GI-related reasons for hospitalization in CF patients. Mean age and mortality was determined for the five major GI-related hospitalization causes.

Results: Diagnosis: Of the 9085 CF patients hospitalized for GI reasons between 2016-2018, 6700 were hospitalized for complaints related to this study (73.7%) and 2385 CF GI hospitalizations did not fit our 5 major categories (26.3%). 17.9% of the patients were hospitalized for pancreatitis (n=1625), including acute pancreatitis and chronic pancreatitis. 1615 patients were hospitalized for GI inflammation and dysmotility (17.8%), including constipation, gastroenteritis and colitis. 1005 patients were hospitalized for obstruction (11.1%), including: paralytic ileus and intestinal obstruction and postprocedural obstruction. 405 patients were admitted for GI procedures and colorectal malignancy (4.5%) including management of ostomies and intestinal adhesions. 2115 CF hospitalizations were for unspecified GI diagnoses (23.3%). Age: Mean age at hospitalization was 22.0 (SE, 0.8) for unspecified diagnosis, 23.7 (SE, 1.0) for GI inflammation and dysmotility, 27.5 (SE, 1.0) for GI obstruction, 27.8 (SE, 2.4) for GI procedures and 30.1 (SE, 0.8) for pancreatitis. Mortality: GI obstruction was a common cause of inpatient mortality (0.5%), followed by pancreatitis (0.3%). Miscellaneous GI diagnosis had a 0.2% mortality incidence. GI procedures, GI inflammation and dysmotility were not associated with inpatient mortality.

Discussion: Pancreatitis, GI inflammation, and GI obstruction were the three most common causes of GI hospitalization in CF patients. The mean age of these patients ranges from 23 to 30 years old. The mortality rate remains < 1% in CF patients, when hospitalized for GI reasons.




Disclosures:


Claire Caplan, MS, BA¹, Colin Wikholm, BS², Akram I. Ahmad, MBBS³, Ioannis Pothoulakis, MD⁴, Loveleen Bhogal, MBBS⁵, Abhinav Sehgal, ², Jang Cho, BA⁶, Sarah Schumacher, BS², Jennie Zhang, DO⁴. P1183 - Most Common Causes of Gastrointestinal Hospitalization in Patients With Cystic Fibrosis, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.