P1804 - Hospitalization Outcomes of Hepatitis A in HIV and Non-HIV Patients

Ali Sawani, MD¹, Mohammad Ahmad, DO¹, Sindu Iska, MD¹, Olugbenga Oyesanmi, MD¹, Shaival Thakore, MD¹, Rahul Mhaskar, PhD², Joseph Staffetti, MD^1
1Regional Medical Center Bayonet Point, Hudson, FL; ²University of South Florida, Tampa, FL

Introduction: Hepatitis A infection (HepA) presents with symptoms of nausea, fatigue, abdominal pain, and malaise. For most individuals, the infection is mild and last only 1 to 2 weeks. Although HepA infection is vaccine preventable, the majority of Americans over the age of 40 are unvaccinated. Individuals with HIV are at an increased risk for developing severe, and often prolonged, HepA infection. In this study, we compared hospitalization outcomes between HIV and non-HIV patients infected with HepA.

Methods: The National Inpatient Sample (NIS) of the Healthcare Cost and Utilization Project (HCUP) was used to obtain data on HepA hospitalizations from 2010 to 2014. ICD-9 codes were used to identify patients with HepA and those with HIV infection. Outcomes including in-hospital mortality, length of stay, total hospitalization charges, and patient demographics were compared between HIV and non-HIV patients.

Results: During the 5 year study period, hospitalization records for 7,604 HepA infections were identified. Of those, 343 (4.5%) were also infected with HIV. The median age of hospitalized HepA patients with HIV was 50, compared with 57 years in non-HIV patients (p< 0.001). HIV patients had a median hospitalization stay of 5 days for HepA infection, which was longer than non-HIV patients who required a 4 day length of stay (p< 0.001). The median hospitalization cost for all patients was $30,794. HIV patients had a slightly higher hospitalization cost compared to non-HIV patients, but this was not statistically significant ($32,811 vs $30,721, p=0.052). HIV patients had higher rates of coinfection with hepatitis B (45.2%) and hepatitis C (32.9%) compared to non-HIV patients (13.8% and 16% respectively, p< 0.001). The overall mortality for all HepA patients was 2.9%. There was no statistically significant difference in HIV patient mortality which was 4.4%, compared to a 2.8% mortality in non-HIV patients (p=0.09).

Discussion: HIV patients hospitalized for HepA infection were younger and required a longer length of stay compared to non-HIV patients. Despite the increased rate of co-infection with hepatitis B and C, there was no significant difference in mortality or total hospitalization charges when comparing HIV and non-HIV patients hospitalized for hepatitis A.


Disclosures:


Ali Sawani, MD¹, Mohammad Ahmad, DO¹, Sindu Iska, MD¹, Olugbenga Oyesanmi, MD¹, Shaival Thakore, MD¹, Rahul Mhaskar, PhD², Joseph Staffetti, MD¹. P1804 - Hospitalization Outcomes of Hepatitis A in HIV and Non-HIV Patients, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.