P0022 - The Role of CK-18 in Predicting Disease Severity in Acute Pancreatitis: A Single Center Prospective Study

Daryl Ramai, MD, MSc¹, Umut Aykut, MD², Tarik Kani, MD², Coskun Demirtas, MD³, Filiz Ozdemir, MD³, Abidin Gundogdu, MD³, Deniz Duman, MD^3
1University of Utah, Salt Lake City, UT; ²Marmara University, Fahrettin Kerim Gökay Cd., Istanbul, Turkey; ³Marmara University, Fahrettin Kerim Gökay Cd, Istanbul, Turkey

Introduction: Acute pancreatitis (AP) is one of the most common gastrointestinal condition which requires hospitalization. Severe pancreatitis has been defined as the presence of persistent organ failure which is associated with high mortality rate. Several prognostic models and biomarkers have been developed to predict the clinical course and severity of AP. Cytokeratin (CK)-18 is involved in important signaling pathways such as apoptosis, cell cycle, and cancer progression that regulate cell behavior. The aim of this study is the clinical value of blood CK-18 level in assessing the disease severity of AP.

Methods: We prospectively enrolled consecutive patients who were admitted to emergency department with the diagnosis of as AP. Their demographic, laboratory, radiologic and clinical data were collected prospectively on admission. Ranson’s score, The Acute Physiology and Chronic Health Evaluation-II (APACHE-II) score, and Systemic Inflammatory Response Syndrome (SIRS) score were e calculated for each patient. We compared CK-18 levels within severe and non-severe forms of acute pancreatitis.

Results: Out of 161 initially enrolled patients, CK-18 was studied in 79 participants. The mean age was 52.1 ± 18.7 years and 35 (44.3%) were female. The most common AP etiology was underlying biliary stone disease (n=40, 50.6%), followed by idiopathic AP (n=16, 20.3%). Severe AP was found in 34, 22 and 7 number of patients according to Ranson’s, APACHE-II and SIRS scores, in CK-18 subgroups, respectively. The median value of CK-18 was indifferent between severe and non-severe AP patients defined by Ranson’s (p value: 0.336), APACHE-II (p-value: 0.926) and SIRS (p value:0.323) criteria. Levels of CK-18 was not found to be correlated with Ranson's (r: -0.028, p:0.818) or APACHE-II (r: -0.014, p:0.906) scores as well.

Discussion: Our study demonstrated that CK-18 was not correlated with AP severity. CK-18 should not be used as a clinical marker for worsening pancreatitis.



Disclosures:


Daryl Ramai, MD, MSc¹, Umut Aykut, MD², Tarik Kani, MD², Coskun Demirtas, MD³, Filiz Ozdemir, MD³, Abidin Gundogdu, MD³, Deniz Duman, MD³. P0022 - The Role of CK-18 in Predicting Disease Severity in Acute Pancreatitis: A Single Center Prospective Study, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.