P0300 - Metformin Use and Risk of Esophageal Cancer Among Asian Populations: A Meta-Analysis

Yue Chen, ¹, Chenyu Sun, MD, MSc², Xingyu Cheng, ¹, Lei Hu, ¹, Na Hyun Kim, MD², Sujatha Kailas, MD², Faisal Qureshi, MD², Zeid Karadsheh, MD³, Chandur Bhan, MD², Keun Young Kim, MD², Raveena Manem, MD², Pratikshya Thapa, MD², Humaed Mohammed Abdul, MD^2
1School of the First Clinical Medicine, Anhui Medical University, Hefei, Anhui, China; ²AMITA Health Saint Joseph Hospital, Chicago, IL; ³AMITA Heath Saint Joseph Hospital, Chicago, IL

Introduction: Results of previous studies on the association between metformin use and esophageal cancer (EC) were controversial. In many Asian areas, squamous cell carcinoma is more common. Therefore, this meta-analysis was conducted to assess the association between metformin and EC in Asian populations.

Methods: A comprehensive search was conducted to select relevant studies in CNKI (China National Knowledge Infrastructure), CBM (China Biomedical Database), the VIP (Chinese), Wanfang (Chinese) Data, Web of Science, Embase, PubMed, and Cochrane Library up to February 2021. Hazard ratios (HRs) with 95% confidence intervals (CI) were pooled through random-effect or fixed-effect model, depending on the heterogeneity which was evaluated through the Q test and I-squared statistic. Sensitivity analysis and publication bias assessment were also conducted. All statistical analysis was performed using STATA 15.1. statistical software (Stata Corp., College Station, TX).

Results: Four studies were included. Metformin use was associated with reduced risk of EC (HR=0.50, 95% CI=0.34-0.73, I²=10.8%)). Heterogeneity was not statistically significant, so a fixed-effect model was used. Heterogeneity was not statistically significant, so a fixed-effect model was used. Sensitivity analysis by omitting one study at a time suggested the results were relatively stable. No publication bias was detected based on the funnel plot, and Egger's test (p=0.798).

Discussion: Overall, metformin is associated with a reduced risk of EC for the Asian population. However, further analysis based on different populations, and subgroup analysis based on different pathohistological types are still needed to provide further evidence.




Disclosures:


Yue Chen, ¹, Chenyu Sun, MD, MSc², Xingyu Cheng, ¹, Lei Hu, ¹, Na Hyun Kim, MD², Sujatha Kailas, MD², Faisal Qureshi, MD², Zeid Karadsheh, MD³, Chandur Bhan, MD², Keun Young Kim, MD², Raveena Manem, MD², Pratikshya Thapa, MD², Humaed Mohammed Abdul, MD². P0300 - Metformin Use and Risk of Esophageal Cancer Among Asian Populations: A Meta-Analysis, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.