P3013 - Understanding the Regional Trends and Discrepancies of Small Intestinal Cancer in the U.S.: Should We Look to the South?

Anas Raed, MD¹, Shreyu Umapathy, ², Amol Sharma, MD¹, Humberto Sifuentes, MD³, John Erikson Yap, MD⁴, Subbaramia Sridhar, MBBS, MPH, FRCP, FRCPC, FACG^5
1Augusta University, Augusta, GA; ²August Georg University, Augusta, GA; ³Medical College of Georgia, Augusta, GA; ⁴Medical College of Georgia at Augusta University, Augusta, GA; ⁵AUMC, Augusta, GA

Introduction: Small intestinal cancer (SIC) is a rare tumor and therefore its epidemiology is poorly understood. The regional distribution of this disease is unknown. Our aim was to determine the incidence rate variations of SIC by geographic location, specifically by regions and states.

Methods:
The data was extracted from the National Program of Cancer Registries (NPCR) and Surveillance, Epidemiology and End Results (SEER) for the period 2001-2016. Age-adjusted incidence and annual percent change (APC) were calculated in a step-wise manner to examine the trends among each of the four US regions, followed by 13 individual SEER-reported states. SEER Stat software was used to analyze the data.

Results: The incidence rates of SIC in population ≥50 & < 50 years have significantly increased in all US regions, with the highest rates of increased incidence in the South with APC of 2.0 (CI: 1.6, 2.5) (table 1). When examining incidence rates of SIC by the states, the rates have increased significantly among population ≥50 in 9 SEER-reported states except Alaska, Hawaii, New Mexico and Washington. Among the states with highest increased rates are Louisiana and Georgia with APC 2.9 (CI: 2.1, 3.8) and 2.7 (CI: 1.7, 3.7) respectively (table 2).

Discussion: Findings from this study highlights a disturbing increase in the incidence of SIC by the geographical location. Further efforts should focus on the widespread adoption of public health preventive, screening, and surveillance approaches to reduce the rising incidence of SIC. Public health organizations should investigate all regions and particularly the Southern region to understand the factors leading to this disturbing disparity.


Disclosures:


Anas Raed, MD¹, Shreyu Umapathy, ², Amol Sharma, MD¹, Humberto Sifuentes, MD³, John Erikson Yap, MD⁴, Subbaramia Sridhar, MBBS, MPH, FRCP, FRCPC, FACG⁵. P3013 - Understanding the Regional Trends and Discrepancies of Small Intestinal Cancer in the U.S.: Should We Look to the South?, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.