Anas Raed, MD1, Amol Sharma, MD1, Subbaramia Sridhar, MBBS, MPH, FRCP, FRCPC, FACG2, John Erikson Yap, MD3, Humberto Sifuentes, MD4 1Augusta University, Augusta, GA; 2AUMC, Augusta, GA; 3Medical College of Georgia at Augusta University, Augusta, GA; 4Medical College of Georgia, Augusta, GA
Introduction: Appendiceal cancer (AC) is a rare malignancy, which accounts for less than 1% of GI tract cancers. The aims of our study were to assess the annual percent change (APC) of AC among the US population younger and older than 50 and to explore the APC among these two populations by gender, race & histology type.
Methods: We utilized the National Program of Cancer Registries (NPCR) and Surveillance, Epidemiology, and End Results (SEER) programs to distinguish all the cases of AC diagnosed between 2001 & 2016. The cases of AC were identified using the the ICD code for Oncology (ICD-O-3), coded as “appendix”. The age-adjusted incidence and APC were then calculated.
Results: There were 46,185 AC cases between 2001 & 2016, with 31,075 (67.3%) cases were 50 years or older. Females comprised 54.1%, Caucasians 86.3%, African-Americans 9.6% and Others 4.1%. A total of 41.6% were carcinoid, 22.6% adenocarcinoma-NOS, 29.7% mucinous & 6.1% signet-ring cell adenocarcinoma. An increase in the incidence rate of AC was noted in both groups since 2001 with higher increase in age group < 50 years with an APC 11 (CI: 8.3, 13.6). With regards to histology, carcinoid and adenocarcinoma-NOS showed higher increase in group < 50 years, while mucinous adenocarcinoma and signet-ring cell adenocarcinoma showed higher increase in group ≥ 50 years. Females had a higher risk than males with APC 8.6 (CI: 7.0, 10.1) vs 6.5 (CI: 5.2, 7.7). Other race had highest risk with APC 8.2 (CI: 6.2, 10.1). Among individuals ≥50 years, age group 50-54 years had the greatest increased risk with APC (6.4, [CI: 5.4, 7.3]). Among individuals < 50 years, age group 25-29 years had the increased risk with APC 17.3, [CI: 13.3, 21.3].
Discussion: The incidence of AC with carcinoid histology is rapidly increasing, especially in women younger than 50 years, with higher rates of increase in “Other” race. Widespread awareness strategies and high quality imaging & colonoscopies are critical to hopefully diminish the disparities of this disease.
Disclosures: Anas Raed indicated no relevant financial relationships. Amol Sharma indicated no relevant financial relationships. Subbaramia Sridhar indicated no relevant financial relationships. John Erikson Yap indicated no relevant financial relationships. Humberto Sifuentes indicated no relevant financial relationships.
Anas Raed, MD1, Amol Sharma, MD1, Subbaramia Sridhar, MBBS, MPH, FRCP, FRCPC, FACG2, John Erikson Yap, MD3, Humberto Sifuentes, MD4. P2209 - Appendiceal Cancer: A Hidden, Inflammatory Assault on Women’s Health, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.